D6WI29 · CGLR_TRICA

Function

function

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:34261127).
Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127).
Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (By similarity).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Activity regulation

The enzyme activity is specifically activated by double-stranded RNA (dsRNA).

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site57ATP (UniProtKB | ChEBI)
Binding site69Mg2+ (UniProtKB | ChEBI); catalytic
Binding site69-71ATP (UniProtKB | ChEBI)
Binding site71Mg2+ (UniProtKB | ChEBI); catalytic
Binding site192GTP (UniProtKB | ChEBI)
Binding site192Mg2+ (UniProtKB | ChEBI); catalytic
Binding site240-247GTP (UniProtKB | ChEBI)
Binding site244-247ATP (UniProtKB | ChEBI)
Binding site265ATP (UniProtKB | ChEBI)
Binding site277-281ATP (UniProtKB | ChEBI)
Binding site288Mn2+ (UniProtKB | ChEBI)
Binding site289Mn2+ (UniProtKB | ChEBI)
Binding site292Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',2'-cyclic GMP-AMP synthase activity
Molecular FunctionATP binding
Molecular Functiondouble-stranded RNA binding
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Biological Processdefense response to virus
Biological Processimmune response involved in response to exogenous dsRNA
Biological Processinnate immune response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic GMP-AMP synthase-like receptor
  • EC number
  • Short names
    Tc-cGLR
    ; cGLR

Gene names

    • ORF names
      TcasGA2_TC003965

Organism names

  • Taxonomic identifier
  • Strain
    • Georgia GA2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium

Accessions

  • Primary accession
    D6WI29

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004544481-398Cyclic GMP-AMP synthase-like receptor

Family & Domains

Sequence similarities

Belongs to the mab-21 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    398
  • Mass (Da)
    46,190
  • Last updated
    2010-08-10 v1
  • Checksum
    0B8219E6FE5FB256
MENILNDINKRFISLPEEDVRGNKQILESVLRTFVEQMKTQDPLFKALFRRVFYGGSFYDGLKVGKPEEFDLDILLHIPIYAQPVLNESNVPGFVWLKLNNLDGWLRQPEGRVYKDFRKKFLADNDFLDTGKTLRWMESLVQKTLNTLPWVNNATCELTNEFGTFHINWWKGGPAMTLGISHSSGEKIMDVDLVACFVFSGDKWPINGYRSNPFPSTKPEFFIVPKKPQGPVNPQGRYWSLSFQEQERVLIDNKNRLKPAVKLIKKLKEKTHPNIASYYIKTVFLHIIEQKDQSFWNKSLREVFMTTLREYNEFIADQSIPYYWCRKNNLIGHLAPITLNNISNRIGYIIKDIENNPENIAKHLLTKEEYTKYIQGEDVMAEALPALPASQTSSCVII

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ971334
EMBL· GenBank· DDBJ
EFA01049.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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