D6WI29 · CGLR_TRICA
- ProteinCyclic GMP-AMP synthase-like receptor
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids398 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (2',3'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:34261127).
Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127).
Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (By similarity).
Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127).
Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 2',3'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (By similarity).
Catalytic activity
- ATP + GTP = 2',3'-cGAMP + 2 diphosphateThis reaction proceeds in the forward direction.
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Activity regulation
The enzyme activity is specifically activated by double-stranded RNA (dsRNA).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 57 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 69 | Mg2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 69-71 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EFD | ||||||
Binding site | 71 | Mg2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 192 | GTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 192 | Mg2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 240-247 | GTP (UniProtKB | ChEBI) | ||||
Sequence: SLSFQEQE | ||||||
Binding site | 244-247 | ATP (UniProtKB | ChEBI) | ||||
Sequence: QEQE | ||||||
Binding site | 265 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 277-281 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SYYIK | ||||||
Binding site | 288 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 289 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 292 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',2'-cyclic GMP-AMP synthase activity | |
Molecular Function | ATP binding | |
Molecular Function | double-stranded RNA binding | |
Molecular Function | GTP binding | |
Molecular Function | metal ion binding | |
Biological Process | defense response to virus | |
Biological Process | immune response involved in response to exogenous dsRNA | |
Biological Process | innate immune response |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCyclic GMP-AMP synthase-like receptor
- EC number
- Short namesTc-cGLR ; cGLR
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium
Accessions
- Primary accessionD6WI29
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454448 | 1-398 | Cyclic GMP-AMP synthase-like receptor | |||
Sequence: MENILNDINKRFISLPEEDVRGNKQILESVLRTFVEQMKTQDPLFKALFRRVFYGGSFYDGLKVGKPEEFDLDILLHIPIYAQPVLNESNVPGFVWLKLNNLDGWLRQPEGRVYKDFRKKFLADNDFLDTGKTLRWMESLVQKTLNTLPWVNNATCELTNEFGTFHINWWKGGPAMTLGISHSSGEKIMDVDLVACFVFSGDKWPINGYRSNPFPSTKPEFFIVPKKPQGPVNPQGRYWSLSFQEQERVLIDNKNRLKPAVKLIKKLKEKTHPNIASYYIKTVFLHIIEQKDQSFWNKSLREVFMTTLREYNEFIADQSIPYYWCRKNNLIGHLAPITLNNISNRIGYIIKDIENNPENIAKHLLTKEEYTKYIQGEDVMAEALPALPASQTSSCVII |
Structure
Sequence
- Sequence statusComplete
- Length398
- Mass (Da)46,190
- Last updated2010-08-10 v1
- Checksum0B8219E6FE5FB256
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ971334 EMBL· GenBank· DDBJ | EFA01049.1 EMBL· GenBank· DDBJ | Genomic DNA |