D6WHJ8 · D6WHJ8_TRICA
- ProteinPurine nucleoside phosphorylase
- GeneAUGUSTUS-3.0.2_03914
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids308 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Catalytic activity
- 2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine
Pathway
Purine metabolism; purine nucleoside salvage.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 53 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 84 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 104-106 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 136 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 221 | a purine D-ribonucleoside (UniProtKB | ChEBI) | |||
Binding site | 240 | phosphate (UniProtKB | ChEBI) | |||
Binding site | 263 | a purine D-ribonucleoside (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | guanosine phosphorylase activity | |
Molecular Function | purine-nucleoside phosphorylase activity | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePurine nucleoside phosphorylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Tenebrionidae > Tenebrionidae incertae sedis > Tribolium
Accessions
- Primary accessionD6WHJ8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-20 | Disordered | |||
Domain | 47-299 | Nucleoside phosphorylase | |||
Sequence similarities
Belongs to the PNP/MTAP phosphorylase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length308
- Mass (Da)34,250
- Last updated2010-08-10 v1
- ChecksumF026A5F7029949C2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ971331 EMBL· GenBank· DDBJ | EFA01001.1 EMBL· GenBank· DDBJ | Genomic DNA |