D6RA83 · D6RA83_HUMAN
- Protein15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- GeneHPGD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD+ = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H+ + NADHThis reaction proceeds in the forward direction.
- 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD+ = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H+ + NADHThis reaction proceeds in the forward direction.
- 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H+ + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD+This reaction proceeds in the forward direction.
- NAD+ + prostaglandin A1 = 15-oxo-prostaglandin A1 + H+ + NADHThis reaction proceeds in the forward direction.
- NAD+ + prostaglandin E1 = 15-oxoprostaglandin E1 + H+ + NADHThis reaction proceeds in the forward direction.
- NAD+ + resolvin D1 = 17-oxoresolvin D1 + H+ + NADHThis reaction proceeds in the forward direction.
- NAD+ + resolvin D1 = 8-oxoresolvin D1 + H+ + NADHThis reaction proceeds in the forward direction.
- NAD+ + resolvin D2 = 16-oxoresolvin D2 + H+ + NADHThis reaction proceeds in the forward direction.
- NAD+ + resolvin D2 = 7-oxoresolvin D2 + H+ + NADHThis reaction proceeds in the forward direction.
- NAD+ + resolvin E1 = 18-oxo-resolvin E1 + H+ + NADHThis reaction proceeds in the forward direction.
- lipoxin A4 + NAD+ = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H+ + NADHThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Molecular Function | oxidoreductase activity | |
Biological Process | prostaglandin metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionD6RA83
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
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The viewer provides 126 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusFragment
- Length99
- Mass (Da)10,696
- Last updated2010-07-13 v1
- Checksum7A1F3768C2B4F95B
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 99 | |||||
Sequence: L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC096751 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |