D6RA83 · D6RA83_HUMAN

  • Protein
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • Gene
    HPGD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

Catalytic activity

  • (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD+ = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H+ + NADH
    This reaction proceeds in the forward direction.
  • (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD+ = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.1.1.232 (UniProtKB | ENZYME | Rhea)
  • 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD+ = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H+ + NADH
    This reaction proceeds in the forward direction.
  • 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H+ + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD+
    This reaction proceeds in the forward direction.
  • NAD+ + prostaglandin A1 = 15-oxo-prostaglandin A1 + H+ + NADH
    This reaction proceeds in the forward direction.
  • NAD+ + prostaglandin E1 = 15-oxoprostaglandin E1 + H+ + NADH
    This reaction proceeds in the forward direction.
  • NAD+ + prostaglandin E2 = 15-oxoprostaglandin E2 + H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.1.1.141 (UniProtKB | ENZYME | Rhea)
  • NAD+ + resolvin D1 = 17-oxoresolvin D1 + H+ + NADH
    This reaction proceeds in the forward direction.
  • NAD+ + resolvin D1 = 8-oxoresolvin D1 + H+ + NADH
    This reaction proceeds in the forward direction.
  • NAD+ + resolvin D2 = 16-oxoresolvin D2 + H+ + NADH
    This reaction proceeds in the forward direction.
  • NAD+ + resolvin D2 = 7-oxoresolvin D2 + H+ + NADH
    This reaction proceeds in the forward direction.
  • NAD+ + resolvin E1 = 18-oxo-resolvin E1 + H+ + NADH
    This reaction proceeds in the forward direction.
  • lipoxin A4 + NAD+ = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H+ + NADH
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Molecular Functionoxidoreductase activity
Biological Processprostaglandin metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • EC number
  • Alternative names
    • Eicosanoid/docosanoid dehydrogenase [NAD(+)]
    • Prostaglandin dehydrogenase 1

Gene names

    • Name
      HPGD

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    D6RA83

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 126 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Expression

Gene expression databases

Structure

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    99
  • Mass (Da)
    10,696
  • Last updated
    2010-07-13 v1
  • Checksum
    7A1F3768C2B4F95B
MSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGIL

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P15428PGDH_HUMANHPGD266
E9PBZ2E9PBZ2_HUMANHPGD176
D6RHF8D6RHF8_HUMANHPGD37
D6RA66D6RA66_HUMANHPGD97
E9PD69E9PD69_HUMANHPGD87

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue99

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC096751
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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