D6R9R1 · D6R9R1_HUMAN

  • Protein
    methylcrotonoyl-CoA carboxylase
  • Gene
    MCCC2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Catalytic activity

Pathway

Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionligase activity
Biological ProcessL-leucine catabolic process

Keywords

  • Molecular function

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    methylcrotonoyl-CoA carboxylase
  • EC number
  • Alternative names
    • 3-methylcrotonyl-CoA carboxylase 2
    • 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit
    • 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta

Gene names

    • Name
      MCCC2
    • ORF names
      hCG_37849

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    D6R9R1

Proteomes

Organism-specific databases

Disease & Variants

Variants

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The viewer provides 345 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)127PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-206CoA carboxyltransferase N-terminal
Domain271-329CoA carboxyltransferase C-terminal

Sequence similarities

Belongs to the AccD/PCCB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    36,337
  • Last updated
    2011-02-08 v2
  • Checksum
    3F76836BC1333B17
MWAVLRLALRPCARASPAGPRAYHGDSVASLGTQPDLGSALYQENYKQMKALVNQLHERVEHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKLDVTIEPSEEPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGIKPLEKHKT

Computationally mapped potential isoform sequences

There are 22 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9HCC0MCCB_HUMANMCCC2563
A0A0S2Z5R4A0A0S2Z5R4_HUMANMCCC2367
D6RDF7D6RDF7_HUMANMCCC2357
D6RD67D6RD67_HUMANMCCC2115
A0A804HHS4A0A804HHS4_HUMANMCCC2368
A0A804HJ31A0A804HJ31_HUMANMCCC2432
A0A804HIQ3A0A804HIQ3_HUMANMCCC258
A0A804HJ24A0A804HJ24_HUMANMCCC2515
A0A804HJ84A0A804HJ84_HUMANMCCC2560
A0A804HIH3A0A804HIH3_HUMANMCCC2363
A0A0D9SFE9A0A0D9SFE9_HUMANMCCC2325
A0A0G2JM88A0A0G2JM88_HUMANMCCC2208
A0A804HLJ9A0A804HLJ9_HUMANMCCC2606
A0A804HK37A0A804HK37_HUMANMCCC2491
A0A804HJW2A0A804HJW2_HUMANMCCC2321
A0A804HJW5A0A804HJW5_HUMANMCCC2342
A0A804HJC1A0A804HJC1_HUMANMCCC2269
A0A804HJL2A0A804HJL2_HUMANMCCC2285
A0A804HKE8A0A804HKE8_HUMANMCCC2533
A0A804HL02A0A804HL02_HUMANMCCC2394
A0A804HKN6A0A804HKN6_HUMANMCCC268
A0A804HKH3A0A804HKH3_HUMANMCCC2156

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC138832
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC143336
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KU178741
EMBL· GenBank· DDBJ
ALQ34199.1
EMBL· GenBank· DDBJ
mRNA
CH471084
EMBL· GenBank· DDBJ
EAW95691.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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