D5X6A9 · D5X6A9_THIK1

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site23-28NAD+ (UniProtKB | ChEBI)
Binding site27NADPH (UniProtKB | ChEBI)
Binding site47NADPH (UniProtKB | ChEBI)
Binding site48NADPH (UniProtKB | ChEBI)
Binding site121NADPH (UniProtKB | ChEBI)
Binding site121sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site121substrate
Binding site150sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site152sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site154NAD+ (UniProtKB | ChEBI)
Binding site154NADPH (UniProtKB | ChEBI)
Active site218Proton acceptor
Binding site218sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site271sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site281sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site282NAD+ (UniProtKB | ChEBI)
Binding site282NADPH (UniProtKB | ChEBI)
Binding site282sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site282-283substrate
Binding site283sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site302NADPH (UniProtKB | ChEBI)
Binding site304NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmembrane
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • Ordered locus names
      Tint_2685

Organism names

Accessions

  • Primary accession
    D5X6A9

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-35Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-169Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain207-343Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    40,890
  • Last updated
    2010-07-13 v1
  • MD5 Checksum
    034F837BEABCB4DF210CC0549F9C0176
MQNSASSFIVGNPTLAPVVAVIGAGAWGTALACALRRGGLEVRLWARRPDLTHAIATQARNPRHLPELELPAGLKASSQMAEVLDGADAVFMVVPSAALREVARAAAPWLQRRAVVLAACKGIERDSGALMTQVLQQELRPGALIGAIGGPSFAHEVVRGQPAALTVGLPALRQRGAVDVQSHAQRLMGGLRTAFAAGQVQLDVTDDAIGVQVGGALKNMIAIACGMAMSCEQGENARAAILTRGLQDMRRLTLALGGRPETLLSSAGAGDLFLTASSAQSRNTRLGMQLGRGEFPGGEGELAEGAISSQSVQILERRLGLHLQVAAVVRDVLGRRQTAEEALRRLLTQPVQQDDALGLPVASGVHAHRLLRDAQGLRPTLSRAQSRQSQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002021
EMBL· GenBank· DDBJ
ADG32026.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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