D5X694 · D5X694_THIK1

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site15-20substrate
Binding site47Mg2+ (UniProtKB | ChEBI)
Active site76Proton acceptor
Binding site76Mg2+ (UniProtKB | ChEBI)
Binding site77substrate
Binding site164-167substrate
Binding site186substrate
Binding site191-192substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      Tint_2670

Organism names

Accessions

  • Primary accession
    D5X694

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region218-255Disordered

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    255
  • Mass (Da)
    26,826
  • Last updated
    2010-07-13 v1
  • MD5 Checksum
    255E647A03E1D9E069FEDECDC584590D
MAAPTSATCRIVLASGNPGKLAELSALLAPLGCQVQPQGEFHLVEADEPHPTFVENALAKARHASFHTGLPALADDSGLCVEALGGLPGVRSARFAPLVEGPRAEQDAANNRLLLQQMEGQTLRLARFVSIVVALRHAADPEPLIVRGELIGQIGHAAQGQGGFGYDPLFVLADGRTLAQCDAQEKNRISHRGQALQTLLPLLRTHWGWTAAASERPQGWAIPTPTLPTSGEGVISPPPRRGGGREGDGPAFPRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002021
EMBL· GenBank· DDBJ
ADG32011.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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