D5X546 · D5X546_THIK1

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site.

1777100200300400500600700
TypeIDPosition(s)Description
Site51Interaction with DNA
Site87Interaction with DNA
Site89Interaction with DNA
Site130Transition state stabilizer
Active site131O-(5'-phospho-DNA)-tyrosine intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular ComponentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
Cellular Componentextrinsic component of plasma membrane
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit A
  • EC number
  • Alternative names
    • Topoisomerase IV subunit A

Gene names

    • Name
      parC
    • Ordered locus names
      Tint_0464

Organism names

Accessions

  • Primary accession
    D5X546

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-492DNA topoisomerase type IIA

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    777
  • Mass (Da)
    84,868
  • Last updated
    2010-07-13 v1
  • Checksum
    CEEF86736AA3BDB7
MSEQATLEFDNRPEDDTDSLALGDYARRAYLDYAISVVKGRALPDVCDGLKPVQRRILYAMWRMGLTADAKPVKSARVVGDVLGRFHPHGDQAAYDALVRLSQDFAQRYPLIDGQGNFGSRDGDGAAAMRYTEARLAPIARLLLGEIDAGTADFIPNYDGSTTEPRLLPARLPFVLLNGASGIAVGMATEIPAHNLREVASACVALLKNPRLELADALALMPGPDFATGGQLISSPQDIAAAYAVGRGSLKVRARWTVEELARGQWQLVINELPHGTSTQMVLEEIEELSNPKIRPGKKALAPEQIALKATLLNLLDTVRDESGREAAVRLVFEPRSSRIDQAEFVNTLLARTSLETSVPINLVMIGTDGKPRQKGLMDILREWVAYRRDTVQRRSKHRLEQVDARIHILEGRQQVLLNLDEVIETIRNSDDPRPALMARFDLTELQADDILDMRLRQLARLEAIRIDKELAAQRTEAAELQKLLADEKAMTRRIISEIEADAKQFGDDRRTLIQAEQRAVAEVKVVDEAVTVIVSQKGWLRVQKGHGLVLSALTFKPGDALYATFECRSVDPLVVLGSDGRAYSMDVADLPGGRGDGQPVTSFIELAPGTQALHYLAGARTTALLLWTAQGFGFVTHISDALSRQRAGKTFVTLEDGDTLQRPLVLDTDADGSPVGRLATLSADGRLLLYPAAEVKTLARGGRGITLMALDAKETLQSVAQLAAERDALLVSGKGRGGTERSATLSAAQQTAYVGKRARRGRKLEVTFKPDRLSRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002021
EMBL· GenBank· DDBJ
ADG29870.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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