D5X1U9 · D5X1U9_THIK1
- ProteinATP-dependent zinc metalloprotease FtsH
- GeneftsH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids635 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein catabolic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent zinc metalloprotease FtsH
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Thiomonas
Accessions
- Primary accessionD5X1U9
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-23 | Helical | ||||
Sequence: FSKIAIWLVIGLVLFTVF | ||||||
Transmembrane | 102-123 | Helical | ||||
Sequence: FLTQIFISWFPMLLLIGVWVYF |
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 188-327 | AAA+ ATPase | ||||
Sequence: IPRGVLLVGPPGTGKTLLAKSIAGEAKVPFFTISGSDFVEMFVGVGAARVRDMFENAKKHAPCIIFVDEIDAVGRHRGAGLGGGNDEREQTLNQMLVEMDGFETNLGVIVIAATNRPDILDPALLRPGRFDRQVYVTLPD | ||||||
Region | 593-635 | Disordered | ||||
Sequence: DIMAGREPRPPKLPPSSGPTSAPRTPSAPATGAAPDAPSATAA | ||||||
Compositional bias | 600-614 | Pro residues | ||||
Sequence: PRPPKLPPSSGPTSA |
Sequence similarities
Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length635
- Mass (Da)70,084
- Last updated2010-07-13 v1
- Checksum92EBD58C97262EC6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 600-614 | Pro residues | ||||
Sequence: PRPPKLPPSSGPTSA |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002021 EMBL· GenBank· DDBJ | ADG31095.1 EMBL· GenBank· DDBJ | Genomic DNA |