D5WYV1 · D5WYV1_THIK1

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site16-195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site195-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1125-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1175-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site440-442L-homocysteine (UniProtKB | ChEBI)
Binding site440-442L-methionine (UniProtKB | ChEBI)
Binding site493L-homocysteine (UniProtKB | ChEBI)
Binding site493L-methionine (UniProtKB | ChEBI)
Binding site524-5255-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5705-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site608L-homocysteine (UniProtKB | ChEBI)
Binding site608L-methionine (UniProtKB | ChEBI)
Binding site6145-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site650Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site650Zn2+ (UniProtKB | ChEBI); catalytic
Binding site652Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site652Zn2+ (UniProtKB | ChEBI); catalytic
Binding site674Zn2+ (UniProtKB | ChEBI); catalytic
Binding site674Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site703Proton donor
Binding site735Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site735Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • Ordered locus names
      Tint_2943

Organism names

Accessions

  • Primary accession
    D5WYV1

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-313Cobalamin-independent methionine synthase MetE N-terminal
Domain435-757Cobalamin-independent methionine synthase MetE C-terminal/archaeal

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    793
  • Mass (Da)
    87,618
  • Last updated
    2010-07-13 v1
  • Checksum
    F156F57417E2AF14
MTTTHILGYPRIGPQRELKFALENFWQGKSSASELQATAAQLRAANWAKQRDAGLHFAAVGDFALYDHMLDTAALLGALPARFGFDARTLGLEQYFALARGNAAQPAMEMTKWFDTNYHYLVPELDSATTFDGGFDALFDRVREAQEAGHAPKPVLVGPLTFLWLSKSHQPGFDRLSLAPALSRAYARVLARLAELGVEWVQLDEPALTLDLDTSWRDLLPTLYAALPVQAGALRPKLLLSTYFESISFAPATLAGLPVDGVHLDLVRAPQQIDLWREALPAQWVLSAGIIDGRNVWRSDLAAALRVLRPLHAALGERLWIAPSCSLLHVPVSLAAEHGAGARLNPEVRPWLAFAEEKLEELRVLATALDQGEDAVRDALRANAEALASRRNCPRVTLPQVRRRVEALSEADARRSAPYAQRIAAQHARLNLPPLPTTTIGSFPQTAEIRAGRAAWRRGELRHTDYLQKMREEIAAVIRKQEDIGLDVLVHGEAERNDMVEFFGEQLWGYTFSAGGWVQSYGSRCVKPPIIWGDVWRPEPMTVDTARHAQALTPRPVKGMLTGPITLLQWSFVRDDLPRDQVALQLALAVRDEVSDLQNAGIAIIQIDEPAFREGLPLKRDNWPQYLSWAVRAFGVSAGVARDDTQIHTHMCYSEFNDILPSIAAMDADVITIETSRSNMELLDGFGAFAYPNDIGPGVYDIHSPRVPSAADMARLLRRAAQLIAPERLWVNPDCGLKTRAWPETEAALRHMVQAARDLRHELQTHGRIAPPPAVAADVKASAHSTCCAHDCA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002021
EMBL· GenBank· DDBJ
ADG32278.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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