D5SQS4 · 4HYPE_PLAL2
- Protein4-hydroxyproline 2-epimerase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids359 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity.
Catalytic activity
- trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 126 | Proton acceptor | ||||
Sequence: C | ||||||
Binding site | 127-128 | substrate | ||||
Sequence: GH | ||||||
Binding site | 248 | substrate | ||||
Sequence: H | ||||||
Binding site | 274 | substrate | ||||
Sequence: D | ||||||
Active site | 278 | Proton donor | ||||
Sequence: C | ||||||
Binding site | 279-280 | substrate | ||||
Sequence: GT |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | 4-hydroxyproline epimerase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxyproline 2-epimerase
- EC number
- Short names4Hyp 2-epimerase; 4HypE
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Planctomycetota > Planctomycetia > Planctomycetales > Planctomycetaceae > Planctopirus
Accessions
- Primary accessionD5SQS4
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000432263 | 1-359 | 4-hydroxyproline 2-epimerase | |||
Sequence: MTYIPRQWIQVVDSHTGGEPTRLIYDGQHWPFAGSREGALTSQESPSPSVLSGLRKAIDRSSLILPKTMSERRQFLETEADWLRTASLLEPRGSDVLVGAILTPPEHASSQAGVVFCNNTGYLGMCGHGMIGVIVSLGQMGLIAPGPVTIDTPVGSIAATWSGSASVTLTNVWSYRYRHAVSLSVPGLGVVTGDIAWGGNWFFLIGEEVHQKSLDLGNLSDLLAYTSQIRSELGRQGIAGAQGAEIDHVELFASCDSSIADSQNFVLCPGGAYDRSPCGTGTSAKLACLVADGKVAEGGLWRQKSIVGSCFQAKALSIREGERGLEVLPQLTGEAYVTGVSTLQIDEADPFRWGILPPQ |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length359
- Mass (Da)38,173
- Last updated2010-07-13 v1
- ChecksumFA0C73B97F92EAF3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001744 EMBL· GenBank· DDBJ | ADG68536.1 EMBL· GenBank· DDBJ | Genomic DNA |