D5LXS0 · D5LXS0_9ANNE

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • OM1
    • OM2
    • OM3
    • Leech_CO1_100
    • Leech_CO1_101
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Clitellata > Hirudinea > Hirudinida > Oceanobdelliformes > Ozobranchidae > Ozobranchus

Accessions

  • Primary accession
    D5LXS0
  • Secondary accessions
    • E2IQH9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane93-113Helical
Transmembrane133-155Helical
Transmembrane167-194Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    24,027
  • Last updated
    2011-05-31 v2
  • Checksum
    24C5ED0CE588C3BA
ILYFMFGGWSAMVGMSLSVIIRLELNQPGSFLNNDQLYNSIITAHGLIMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRLNNLSFWLMPPSMIMLVGSALVENGVGTGWTVYPPLSGNIAHSGPSVDMAIFSLHLAGTSSILGSINFITTIINMRWQGMRLERMPLFVWAVLITVVLLLLSLPVFAAAITMLLTDRNLNTSFFDPVGGGDPVLYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU985467
EMBL· GenBank· DDBJ
ADE74591.2
EMBL· GenBank· DDBJ
Genomic DNA
HM590711
EMBL· GenBank· DDBJ
ADN32828.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ451405
EMBL· GenBank· DDBJ
AIA79604.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ451406
EMBL· GenBank· DDBJ
AIA79605.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ451407
EMBL· GenBank· DDBJ
AIA79606.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481288
EMBL· GenBank· DDBJ
QJT93271.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481289
EMBL· GenBank· DDBJ
QJT93272.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481290
EMBL· GenBank· DDBJ
QJT93273.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481291
EMBL· GenBank· DDBJ
QJT93274.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481292
EMBL· GenBank· DDBJ
QJT93275.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481293
EMBL· GenBank· DDBJ
QJT93276.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481294
EMBL· GenBank· DDBJ
QJT93277.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481295
EMBL· GenBank· DDBJ
QJT93278.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481296
EMBL· GenBank· DDBJ
QJT93279.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481297
EMBL· GenBank· DDBJ
QJT93280.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481298
EMBL· GenBank· DDBJ
QJT93281.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481300
EMBL· GenBank· DDBJ
QJT93283.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481301
EMBL· GenBank· DDBJ
QJT93284.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481302
EMBL· GenBank· DDBJ
QJT93285.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481303
EMBL· GenBank· DDBJ
QJT93286.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481304
EMBL· GenBank· DDBJ
QJT93287.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481305
EMBL· GenBank· DDBJ
QJT93288.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481306
EMBL· GenBank· DDBJ
QJT93289.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481307
EMBL· GenBank· DDBJ
QJT93290.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481308
EMBL· GenBank· DDBJ
QJT93291.1
EMBL· GenBank· DDBJ
Genomic DNA
MN481309
EMBL· GenBank· DDBJ
QJT93292.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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