D5LXS0 · D5LXS0_9ANNE
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Clitellata > Hirudinea > Hirudinida > Oceanobdelliformes > Ozobranchidae > Ozobranchus
Accessions
- Primary accessionD5LXS0
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: FGGWSAMVGMSLSVIIRLEL | ||||||
Transmembrane | 37-59 | Helical | ||||
Sequence: LYNSIITAHGLIMIFFMVMPILI | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: MIMLVGSALVENGVGTGWTVY | ||||||
Transmembrane | 133-155 | Helical | ||||
Sequence: SLHLAGTSSILGSINFITTIINM | ||||||
Transmembrane | 167-194 | Helical | ||||
Sequence: LFVWAVLITVVLLLLSLPVFAAAITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-219 | Cytochrome oxidase subunit I profile | ||||
Sequence: ILYFMFGGWSAMVGMSLSVIIRLELNQPGSFLNNDQLYNSIITAHGLIMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRLNNLSFWLMPPSMIMLVGSALVENGVGTGWTVYPPLSGNIAHSGPSVDMAIFSLHLAGTSSILGSINFITTIINMRWQGMRLERMPLFVWAVLITVVLLLLSLPVFAAAITMLLTDRNLNTSFFDPVGGGDPVLYQHLF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)24,027
- Last updated2011-05-31 v2
- Checksum24C5ED0CE588C3BA
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: I | ||||||
Non-terminal residue | 219 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU985467 EMBL· GenBank· DDBJ | ADE74591.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM590711 EMBL· GenBank· DDBJ | ADN32828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451405 EMBL· GenBank· DDBJ | AIA79604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451406 EMBL· GenBank· DDBJ | AIA79605.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451407 EMBL· GenBank· DDBJ | AIA79606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481288 EMBL· GenBank· DDBJ | QJT93271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481289 EMBL· GenBank· DDBJ | QJT93272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481290 EMBL· GenBank· DDBJ | QJT93273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481291 EMBL· GenBank· DDBJ | QJT93274.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481292 EMBL· GenBank· DDBJ | QJT93275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481293 EMBL· GenBank· DDBJ | QJT93276.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481294 EMBL· GenBank· DDBJ | QJT93277.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481295 EMBL· GenBank· DDBJ | QJT93278.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481296 EMBL· GenBank· DDBJ | QJT93279.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481297 EMBL· GenBank· DDBJ | QJT93280.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481298 EMBL· GenBank· DDBJ | QJT93281.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481300 EMBL· GenBank· DDBJ | QJT93283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481301 EMBL· GenBank· DDBJ | QJT93284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481302 EMBL· GenBank· DDBJ | QJT93285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481303 EMBL· GenBank· DDBJ | QJT93286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481304 EMBL· GenBank· DDBJ | QJT93287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481305 EMBL· GenBank· DDBJ | QJT93288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481306 EMBL· GenBank· DDBJ | QJT93289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481307 EMBL· GenBank· DDBJ | QJT93290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481308 EMBL· GenBank· DDBJ | QJT93291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481309 EMBL· GenBank· DDBJ | QJT93292.1 EMBL· GenBank· DDBJ | Genomic DNA |