D5LXR8 · D5LXR8_9ANNE
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Clitellata > Hirudinea > Hirudinida > Oceanobdelliformes > Ozobranchidae > Ozobranchus
Accessions
- Primary accessionD5LXR8
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: FGAWSAMVGMSLSVIIRLEL | ||||||
Transmembrane | 37-59 | Helical | ||||
Sequence: LYNTVITAHGLIMIFFMVMPILI | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: MIMLIGSALVENGVGTGWTVY | ||||||
Transmembrane | 133-155 | Helical | ||||
Sequence: SLHLAGTSSILGSINFITTIINM | ||||||
Transmembrane | 167-194 | Helical | ||||
Sequence: LFVWAVLITVVLLLLSLPVFAAAITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-219 | Cytochrome oxidase subunit I profile | ||||
Sequence: ILYFMFGAWSAMVGMSLSVIIRLELNQPGSFLNNDQLYNTVITAHGLIMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRLNNLSFWLMPPSMIMLIGSALVENGVGTGWTVYPPLSGNIAHSGPSVDMAIFSLHLAGTSSILGSINFITTIINMRWQGMRLERMPLFVWAVLITVVLLLLSLPVFAAAITMLLTDRNLNTSFFDPVGGGDPVLYQHLF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)24,055
- Last updated2010-06-15 v1
- Checksum22B32FF716A0AE68
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: I | ||||||
Non-terminal residue | 219 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GU985465 EMBL· GenBank· DDBJ | ADE74589.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728206 EMBL· GenBank· DDBJ | AHY39159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728207 EMBL· GenBank· DDBJ | AHY39160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728208 EMBL· GenBank· DDBJ | AHY39161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728209 EMBL· GenBank· DDBJ | AHY39162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728210 EMBL· GenBank· DDBJ | AHY39163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728211 EMBL· GenBank· DDBJ | AHY39164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728212 EMBL· GenBank· DDBJ | AHY39165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF728213 EMBL· GenBank· DDBJ | AHY39166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451399 EMBL· GenBank· DDBJ | AIA79598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451400 EMBL· GenBank· DDBJ | AIA79599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451401 EMBL· GenBank· DDBJ | AIA79600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451402 EMBL· GenBank· DDBJ | AIA79601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ451403 EMBL· GenBank· DDBJ | AIA79602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481310 EMBL· GenBank· DDBJ | QJT93293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481311 EMBL· GenBank· DDBJ | QJT93294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481312 EMBL· GenBank· DDBJ | QJT93295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481313 EMBL· GenBank· DDBJ | QJT93296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481314 EMBL· GenBank· DDBJ | QJT93297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481315 EMBL· GenBank· DDBJ | QJT93298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481316 EMBL· GenBank· DDBJ | QJT93299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481317 EMBL· GenBank· DDBJ | QJT93300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481318 EMBL· GenBank· DDBJ | QJT93301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481319 EMBL· GenBank· DDBJ | QJT93302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481320 EMBL· GenBank· DDBJ | QJT93303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481321 EMBL· GenBank· DDBJ | QJT93304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481322 EMBL· GenBank· DDBJ | QJT93305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481323 EMBL· GenBank· DDBJ | QJT93306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481324 EMBL· GenBank· DDBJ | QJT93307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481325 EMBL· GenBank· DDBJ | QJT93308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481326 EMBL· GenBank· DDBJ | QJT93309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481327 EMBL· GenBank· DDBJ | QJT93310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481328 EMBL· GenBank· DDBJ | QJT93311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481329 EMBL· GenBank· DDBJ | QJT93312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481330 EMBL· GenBank· DDBJ | QJT93313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481331 EMBL· GenBank· DDBJ | QJT93314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481332 EMBL· GenBank· DDBJ | QJT93315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481333 EMBL· GenBank· DDBJ | QJT93316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481338 EMBL· GenBank· DDBJ | QJT93321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481339 EMBL· GenBank· DDBJ | QJT93322.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481340 EMBL· GenBank· DDBJ | QJT93323.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481341 EMBL· GenBank· DDBJ | QJT93324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481342 EMBL· GenBank· DDBJ | QJT93325.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481343 EMBL· GenBank· DDBJ | QJT93326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481344 EMBL· GenBank· DDBJ | QJT93327.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481346 EMBL· GenBank· DDBJ | QJT93329.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481347 EMBL· GenBank· DDBJ | QJT93330.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481348 EMBL· GenBank· DDBJ | QJT93331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481349 EMBL· GenBank· DDBJ | QJT93332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481350 EMBL· GenBank· DDBJ | QJT93333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481351 EMBL· GenBank· DDBJ | QJT93334.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481352 EMBL· GenBank· DDBJ | QJT93335.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481353 EMBL· GenBank· DDBJ | QJT93336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481354 EMBL· GenBank· DDBJ | QJT93337.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481358 EMBL· GenBank· DDBJ | QJT93341.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481359 EMBL· GenBank· DDBJ | QJT93342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481360 EMBL· GenBank· DDBJ | QJT93343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481361 EMBL· GenBank· DDBJ | QJT93344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481362 EMBL· GenBank· DDBJ | QJT93345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481363 EMBL· GenBank· DDBJ | QJT93346.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN481364 EMBL· GenBank· DDBJ | QJT93347.1 EMBL· GenBank· DDBJ | Genomic DNA |