D5BD31 · D5BD31_ZUNPS
- ProteinHistidinol dehydrogenase
- GenehisD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids427 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity
- L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 124 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 186 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 209 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 233 | substrate | |||
Binding site | 255 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 255 | substrate | |||
Binding site | 258 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 258 | substrate | |||
Active site | 322 | Proton acceptor | |||
Active site | 323 | Proton acceptor | |||
Binding site | 323 | substrate | |||
Binding site | 356 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 356 | substrate | |||
Binding site | 410 | substrate | |||
Binding site | 415 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 415 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | histidinol dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistidinol dehydrogenase
- EC number
- Short namesHDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Zunongwangia
Accessions
- Primary accessionD5BD31
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length427
- Mass (Da)46,201
- Last updated2010-06-15 v1
- MD5 Checksum9F96868A5271EB1B20A87A79BC77D6B1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001650 EMBL· GenBank· DDBJ | ADF52711.1 EMBL· GenBank· DDBJ | Genomic DNA |