D5BD31 · D5BD31_ZUNPS

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site124NAD+ (UniProtKB | ChEBI)
Binding site186NAD+ (UniProtKB | ChEBI)
Binding site209NAD+ (UniProtKB | ChEBI)
Binding site233substrate
Binding site255Zn2+ (UniProtKB | ChEBI)
Binding site255substrate
Binding site258Zn2+ (UniProtKB | ChEBI)
Binding site258substrate
Active site322Proton acceptor
Active site323Proton acceptor
Binding site323substrate
Binding site356Zn2+ (UniProtKB | ChEBI)
Binding site356substrate
Binding site410substrate
Binding site415Zn2+ (UniProtKB | ChEBI)
Binding site415substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • Ordered locus names
      ZPR_2387

Organism names

Accessions

  • Primary accession
    D5BD31

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    427
  • Mass (Da)
    46,201
  • Last updated
    2010-06-15 v1
  • MD5 Checksum
    9F96868A5271EB1B20A87A79BC77D6B1
MNKIYNPSQSEWEVVLKRPTKTVDDIEDTVNQIFAEVKAKGDTAVAKYTDMFDGIKLENTLVTSEEIATAEAEISEELKSAILLAKKNIEKFHAAQKTTKVEIETTSGVKCWQEKRPIQKIGLYIPGGSAPLFSTILMLAVPAAIAGCKEIVLCTPPNKEGKVHPAILYTANLCGVTKINKIGGIQAIAALTFGTETVPKVYKIFGPGNQFVTVAKQLATRHNVSIDMPAGPSELLVVADDSANPAYVASDLLSQAEHGADSQVILVSTSKTFLDAVEVEVENQLSALPRKAIAEKAIENSKLIYVENDEIALDLINEYGPEHFIISTENNDFYTEGIINAGSVFIGNYTPESAGDYASGTNHTLPTNGYAKQYSGVNLDSFMKSMTFQQISEEGIKSIGPAIELMAEAEGLQAHKNAVTLRLKDLN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001650
EMBL· GenBank· DDBJ
ADF52711.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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