D5B9L6 · D5B9L6_ZUNPS
- ProteinMercuric reductase
- GenemerA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids547 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
Catalytic activity
- Hg + NADP+ + H+ = Hg2+ + NADPH
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 128 | FAD (UniProtKB | ChEBI) | |||
Binding site | 255-262 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 278 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 347 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 388 | FAD (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | mercury (II) reductase (NADP+) activity | |
Molecular Function | mercury ion binding | |
Molecular Function | NAD(P)H dehydrogenase (quinone) activity | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | |
Biological Process | detoxification of mercury ion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMercuric reductase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Zunongwangia
Accessions
- Primary accessionD5B9L6
Proteomes
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 119↔124 | Redox-active | |||
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-69 | HMA | |||
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length547
- Mass (Da)58,854
- Last updated2010-06-15 v1
- MD5 Checksum65561DF67AEB20CC919F678BE5544921
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001650 EMBL· GenBank· DDBJ | ADF54329.1 EMBL· GenBank· DDBJ | Genomic DNA |