D5A8A1 · D5A8A1_PICSI

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14IMP (UniProtKB | ChEBI)
Active site25
Binding site28IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site108IMP (UniProtKB | ChEBI)
Binding site123IMP (UniProtKB | ChEBI)
Binding site183-189substrate
Binding site187IMP (UniProtKB | ChEBI)
Binding site189GTP (UniProtKB | ChEBI)
Binding site215-217GTP (UniProtKB | ChEBI)
Binding site298-300GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase, chloroplastic
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • Name
      PURA

Organism names

Accessions

  • Primary accession
    D5A8A1

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    309
  • Mass (Da)
    33,826
  • Last updated
    2010-06-15 v1
  • Checksum
    A7AD2470EF63513A
MREAELAGSLIGTTKRGIGPCYASKVIRNGIRVSDLRHMDTFPEKLDILLHDAASRFKGFEYSKSMLQTEVEHYKRYSERVEPYIAVTVHLMHDAFSSGKRILVEGGQATMLDVDFGTYPFVTSSNPSAGGICTGLGIAPRHIGDLIGVAKAYTTRVGSGPYPTELLDEAGENLRSAGYEYGTTTGRPRRCGWLDLVALKYSCQINGFSTLNLTKLDVLSGLSRIRLGVAYKGPDGNVLPSFPADLDLLQQVEVIYENLPGWQADISSVRRYQDLPSAACLYVERIESLLGIPINYIGVGPSRDALIVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BT122386
EMBL· GenBank· DDBJ
ADE75770.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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