D4ZBI2 · D4ZBI2_SHEVD

Function

function

Catalyzes cross-linking of the peptidoglycan cell wall.

Catalytic activity

  • Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
    EC:3.4.16.4 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

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TypeIDPosition(s)Description
Active site332Acyl-ester intermediate

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan L,D-transpeptidase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidoglycan D,D-transpeptidase MrdA
  • EC number
  • Alternative names
    • Penicillin-binding protein 2
      (PBP-2
      )

Gene names

    • Name
      mrdA
    • Ordered locus names
      SVI_3406

Organism names

Accessions

  • Primary accession
    D4ZBI2

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein
Cell membrane
Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-42Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain66-241Penicillin-binding protein dimerisation
Domain273-605Penicillin-binding protein transpeptidase

Sequence similarities

Belongs to the transpeptidase family. MrdA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    618
  • Mass (Da)
    69,580
  • Last updated
    2010-06-15 v1
  • Checksum
    3113A4AA7D5DB1BC
MALRKRVTMHDHAAEAALFKRRALFTFVCVTILLAILLTNLYHLQITSYKDYETRSNDNRIRVVPVAPSRGLIYDRNGVLLAENQPFYSLELIPEKVKDIPETLIELSRVIPISADEQEDFIKSLKHHRRFKPLTLKNRLTEEQVALFSVNQHKYPGITVVAGLKRYYPYSELLTHALGYVGRINDRDKSALQRSEQWKDYAGTKDIGKLGIEKYYERLLHGKPGHLEEEVNNRGRTIRTLKSVAPEPGQDIYLTLDLELQRKAVELLNGRRGSVVAIDPRDGGILALVSSPSYDPNLFVHGISSKAYGKLLNSSARPLINRATQGQYAPASTVKPLLALLGLDEKIVTSKTRVWDPGFWQIPGVKHKYRDWQRWGHGWVDVKAALIHSCDTYFYDLAYKTGVNKIAQFMGPFGFGERTGVDISEESAGIMPSKDWKRLRYNQPWYIGDTISVGIGQGYWTATPLQLANATAILAAKGRRFTPHFLKSVKNDSTQIDSSDNELPPIKLNMPENWDIVTEAMRDTAHKKRFKDSPYTAAMKTGTAQVIGVAQDTRYDASAIKEHFRDNALTIAYAPFEAPKIVVAVVLENAGWGGVNAGPVAKSLLDEYMLRDTVESLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP011177
EMBL· GenBank· DDBJ
BAJ03377.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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