D4VT96 · D4VT96_9BACE
- ProteinImidazole glycerol phosphate synthase subunit HisF
- GenehisF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids251 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Catalytic activity
- 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H+
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 11 | ||||
Active site | 130 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | imidazoleglycerol-phosphate synthase activity | |
Molecular Function | lyase activity | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameImidazole glycerol phosphate synthase subunit HisF
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageBacteria > Bacteroidota > Bacteroidia > Bacteroidales > Bacteroidaceae > Bacteroides
Accessions
- Primary accessionD4VT96
Proteomes
Subcellular Location
Interaction
Subunit
Heterodimer of HisH and HisF.
Structure
Sequence
- Sequence statusComplete
- Length251
- Mass (Da)27,001
- Last updated2010-06-15 v1
- MD5 Checksum2CD1113A729135558E28C6C671C3371A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CBXG010000021 EMBL· GenBank· DDBJ | CDM04484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CBXG010000029 EMBL· GenBank· DDBJ | CDM04860.1 EMBL· GenBank· DDBJ | Genomic DNA |