D4VJ45 · D4VJ45_9BACE

Function

function

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site203substrate
Binding site232substrate
Binding site261substrate
Binding site297substrate
Binding site317-319substrate
Binding site358-361substrate
Binding site397substrate
Binding site401Zn2+ (UniProtKB | ChEBI)
Binding site424substrate
Binding site465Zn2+ (UniProtKB | ChEBI)
Binding site541[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site544[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site549[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-carbon lyase activity
Molecular Functionzinc ion binding
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomethylpyrimidine synthase
  • EC number
  • Alternative names
    • Hydroxymethylpyrimidine phosphate synthase
      (HMP-P synthase
      ; HMP-phosphate synthase
      ; HMPP synthase
      )
    • Thiamine biosynthesis protein ThiC

Gene names

    • Name
      thiC
    • ORF names
      BN890_34410

Organism names

Accessions

  • Primary accession
    D4VJ45

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-88ThiC-associated

Sequence similarities

Belongs to the ThiC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    565
  • Mass (Da)
    63,987
  • Last updated
    2010-06-15 v1
  • MD5 Checksum
    E98E1589EE13A41152BDD60C76FF6F3C
MEQKIKFPRSQKVYLPGKLYPNIRVAMRKVEQVPSVSFEGEEKIATPNPEIYVYDTSGPFSDAEMNIDLKKGLPRMREEWIVSRGDVEQLPEITSEYGQMRRDDKSLDHLRFEHIALPYRAKKGEAITQMAYAKRGIITPEMEYVAIRENMNCEELGIKTHITPEFVRQEIAEGRAVLPANINHPEAEPMIIGRNFLVKINTNIGNSATTSSIDEEVEKALWSCKWGGDTLMDLSTGENIHETREWIIRNCPVPVGTVPIYQALEKVNGIVEDLTWEIYRDTLIEQCEQGVDYFTIHAGIRRHNVHLADNRLCGIVSRGGSIMSKWCLVHDQESFLYDHFDDICDILAQYDVAVSLGDGLRPGSIYDANDEAQFAELDTMGELVLRAWDKNVQAFIEGPGHVPMHKIKENMERQIEKCHDAPFYTLGPLVTDIAPGYDHITSAIGAAQIGWLGTAMLCYVTPKEHLALPDKEDVRVGVITYKIAAHAADLAKGHPGAQVRDNALSKARYEFRWKDQFDLSLDPERAQTYFRAGHHIDGEYCTMCGPNFCAMRLSRDLKKSTKSNK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CBXG010000039
EMBL· GenBank· DDBJ
CDM05848.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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