D4VGI0 · D4VGI0_9BACE

Function

function

Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

Miscellaneous

A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-sugar metabolism; N-acetylmuramate degradation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site78Proton donor
Active site109

GO annotations

AspectTerm
Molecular Functioncarbohydrate derivative binding
Molecular Functioncarbon-oxygen lyase activity
Molecular Functionether hydrolase activity
Biological Processamino sugar catabolic process
Biological ProcessN-acetylmuramic acid catabolic process
Biological Processpeptidoglycan turnover

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylmuramic acid 6-phosphate etherase
  • EC number
  • Short names
    MurNAc-6-P etherase
  • Alternative names
    • N-acetylmuramic acid 6-phosphate hydrolase
    • N-acetylmuramic acid 6-phosphate lyase

Gene names

    • Name
      murQ
    • ORF names
      BN890_29980

Organism names

Accessions

  • Primary accession
    D4VGI0

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-213SIS

Sequence similarities

Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    268
  • Mass (Da)
    29,338
  • Last updated
    2010-06-15 v1
  • Checksum
    F22563DB7B53BEA2
MQITEQPSLYDHLEKKSVREILEDINQEDQKVALAVQKAIPQIEELVNQIVPRMKQGGRIFYMGAGTSGRLGVLDASEIPPTFGMSPNWIIGLIAGGDTALRNPVEGAEDNENRGWEELVEHQINEKDTVIGIAASGTTPYVIGALREARRHGVLTGCITSNPDSPMAAEADVAIEMIVGPEYVTGSSRMKSGTGQKMILNMISTSVMIQLGRVKGNKMVNMQLTNHKLIERGTQMIMDELGLDHDRAQKLLLLHGSVKKAIDAYQHS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CBXG010000035
EMBL· GenBank· DDBJ
CDM05408.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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