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D4S3H6 · D4S3H6_9FIRM

Function

function

Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Quinol/quinone metabolism; menaquinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site60[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site64[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site67[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
Molecular Functionaminodeoxyfutalosine synthase activity
Molecular Functioniron ion binding
Biological Processmenaquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminodeoxyfutalosine synthase
  • EC number
  • Short names
    AFL synthase
    ; Aminofutalosine synthase
  • Alternative names
    • Menaquinone biosynthetic enzyme MqnE

Gene names

    • Name
      mqnE
    • ORF names
      HMPREF7545_0091

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 43541
  • Taxonomic lineage
    Bacteria > Bacillota > Negativicutes > Selenomonadales > Selenomonadaceae > Selenomonas

Accessions

  • Primary accession
    D4S3H6

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain46-281Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. MqnE family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    356
  • Mass (Da)
    39,909
  • Last updated
    2010-06-15 v1
  • MD5 Checksum
    02BA07494370A2813A2DF541EC749DE0
MDIEKKIAHGERLTYEDGVRLFACHDIAWIGALADRVRQKKCGDIVYYNVNCHVNLTNICLAHCKFCAFGRDAEDKGAYEMSVEEAVAHVADAMRDPHLAGLHVVSGLHPDWTFDDYLMRLKALHEAFPSLYLKGFTGVEITHFAKTSRLSVREVLVRLRAAGLQSIAGGGAEILSDRVRGELCPNKATADEWLMVARTAHELGIKTNASMLYGHIETVEERVEHMMRLRDLQDETGGFQTFIPFPFLPSNTELGQTVRQTSMWDDLRTIAISRLMLDNFRNIKAYWVMLTVPVAQIALGFGANDIDGTVHKETILHDAGAKSPRALSEDHIIRIIREIGRTPAACDSNFNIIETY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACKT01000005
EMBL· GenBank· DDBJ
EFF67151.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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