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D4S3H3 · D4S3H3_9FIRM

Function

function

Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Quinol/quinone metabolism; menaquinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site50[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site54[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site57[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
Molecular Functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Processmenaquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic dehypoxanthine futalosine synthase
  • EC number
  • Short names
    Cyclic DHFL synthase
  • Alternative names
    • Dehypoxanthine futalosine cyclase
      (DHFL cyclase
      )
    • Menaquinone biosynthetic enzyme MqnC

Gene names

    • Name
      mqnC
    • ORF names
      HMPREF7545_0088

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 43541
  • Taxonomic lineage
    Bacteria > Bacillota > Negativicutes > Selenomonadales > Selenomonadaceae > Selenomonas

Accessions

  • Primary accession
    D4S3H3

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-265Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. MqnC family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    38,444
  • Last updated
    2010-06-15 v1
  • MD5 Checksum
    C87B2991C335BCC0D515F9C9DABBC7BB
MRLTEQEAADLLTHGDPIELGRAADAERRRRFGDTVTFIVDRNINYTNICVNECRFCAFYTKQDAEDAYLLPLEEILAKVGETAAAGGTQVMIQGGIHPDLPLSYYEDMLRAIRSRYPSIVIHSFTATEILYFAQKEGLTVEDTLRRLQDAGLSSLPGGGAEILVDRVRKLIAPKKIMTEDWLRVMRTAHKIGMKSTATMVIGFGETMAERVEHMEHIRRLQEETGGFRAFITWTFQPGNTALGGEKTSSWDYMRTLALTRLYMDNVAHIQGSWVTQGERIGQLTLGFGADDLGSIMLEENVVRAAGTRYNMSIKKMIDLIHGAGREPAQRDTQYRVIRRF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACKT01000005
EMBL· GenBank· DDBJ
EFF67148.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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