D4Q8I2 · D4Q8I2_RAT

Function

Features

Showing features for dna binding.

148850100150200250300350400450
TypeIDPosition(s)Description
DNA binding396-482Fork-head

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Functionhistone acetyltransferase binding
Molecular Functionhistone deacetylase binding
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular FunctionNFAT protein binding
Molecular Functionprotein homodimerization activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific DNA binding
Molecular Functionsequence-specific double-stranded DNA binding
Molecular Functiontranscription corepressor activity
Biological Processalpha-beta T cell proliferation
Biological ProcessB cell homeostasis
Biological ProcessCD4-positive, alpha-beta T cell differentiation
Biological ProcessCD4-positive, alpha-beta T cell proliferation
Biological ProcessCD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Biological Processchromatin remodeling
Biological ProcessDNA-templated transcription
Biological Processestablishment of endothelial blood-brain barrier
Biological Processgene expression
Biological Processimmature T cell proliferation in thymus
Biological Processinflammatory response
Biological Processisotype switching to IgE isotypes
Biological Processlymphocyte proliferation
Biological Processmyeloid cell homeostasis
Biological Processnegative regulation of alpha-beta T cell proliferation
Biological Processnegative regulation of CD4-positive, alpha-beta T cell proliferation
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of chronic inflammatory response
Biological Processnegative regulation of CREB transcription factor activity
Biological Processnegative regulation of cytokine production
Biological Processnegative regulation of defense response to virus
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of immune response
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of interleukin-10 production
Biological Processnegative regulation of interleukin-17 production
Biological Processnegative regulation of interleukin-2 production
Biological Processnegative regulation of interleukin-4 production
Biological Processnegative regulation of interleukin-5 production
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of isotype switching to IgE isotypes
Biological Processnegative regulation of lymphocyte proliferation
Biological Processnegative regulation of NF-kappaB transcription factor activity
Biological Processnegative regulation of T cell cytokine production
Biological Processnegative regulation of T cell proliferation
Biological Processnegative regulation of T-helper 17 cell differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of tumor necrosis factor production
Biological Processnegative regulation of type II interferon production
Biological Processpositive regulation of CD4-positive, alpha-beta T cell differentiation
Biological Processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of immature T cell proliferation in thymus
Biological Processpositive regulation of interleukin-4 production
Biological Processpositive regulation of peripheral T cell tolerance induction
Biological Processpositive regulation of regulatory T cell differentiation
Biological Processpositive regulation of T cell anergy
Biological Processpositive regulation of T cell tolerance induction
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transforming growth factor beta1 production
Biological Processregulation of immunoglobulin production
Biological Processregulation of isotype switching to IgG isotypes
Biological Processregulation of T cell anergy
Biological Processregulation of transcription by RNA polymerase II
Biological Processregulatory T cell differentiation
Biological Processresponse to lipopolysaccharide
Biological Processresponse to rapamycin
Biological Processresponse to virus
Biological ProcessT cell activation
Biological ProcessT cell anergy
Biological ProcessT cell mediated immunity
Biological ProcessT cell proliferation
Biological ProcessT cell receptor signaling pathway
Biological ProcessT cell tolerance induction
Biological Processtolerance induction
Biological Processtolerance induction to self antigen
Biological Processtranscription by RNA polymerase II
Biological Processtransforming growth factor beta1 production

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • Forkhead box P3

Gene names

    • Name
      Foxp3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D4Q8I2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region39-127Disordered
Compositional bias43-57Polar residues
Compositional bias64-78Pro residues
Compositional bias110-126Polar residues
Domain396-482Fork-head

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    488
  • Mass (Da)
    53,932
  • Last updated
    2010-06-15 v1
  • Checksum
    18D0B134E172ACFC
MWQFPTSQADPSLSVHFTQVSVPALPHQTQLCWRKWQGRSVRSPPVQPDTLQPASDKNLMPNPRPAKPMAPSLAPGPSPGGLPSWKTAPKGSELLGTRGPGGPFQGRDLRSGAHTSSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHGHTPVLQVRPLDNPAMIGLPPPTAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKAFEEPGEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALTKAPPVASVDKSSCCLVATSTQGSVLPAWSSPREASDSLFAVRRHLWGSHGNSTFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPSKCSNPCP

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3ZKI1D3ZKI1_RATFoxp3394
D4Q8I3D4Q8I3_RATFoxp3335
A0A8I6G4G9A0A8I6G4G9_RATFoxp3402

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias43-57Polar residues
Compositional bias64-78Pro residues
Compositional bias110-126Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB232989
EMBL· GenBank· DDBJ
BAJ05811.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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