D4PAR3 · D4PAR3_PIG

  • Protein
    Toll-like receptor 4
  • Gene
    TLR4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentearly endosome
Cellular Componentmembrane
Cellular Componentruffle
Molecular Functiontransmembrane signaling receptor activity
Biological Processinflammatory response
Biological Processinnate immune response
Biological Processtoll-like receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Toll-like receptor 4

Gene names

    • Name
      TLR4

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    D4PAR3

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Cell projection, ruffle
Early endosome

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane633-657Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_501111665724-841Toll-like receptor 4

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain673-816TIR

Sequence similarities

Belongs to the Toll-like receptor family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    841
  • Mass (Da)
    96,300
  • Last updated
    2010-05-18 v1
  • Checksum
    572FFF7AD1A24165
MIPRIRLAVATIPAMAFLSCLRSESWDPCVQVVPNISYQCMELNFYKIPDNIPTSVKILDLSFNYLSHLDSNSFSSFPELQVLDLSRCEIQTIDDDAYQGLNYLSTLTLTGNPIQSLALGAFSGLPSLQKLVAVETNLASLEDFPIGHLKTLKELNVAHNHIHSFKLPEYFSNLPNLEHLDLSKNKIENIYHEHSQVLHQVPLLNLSLDLSLNPLNFIEPGAFNKIRLNGLTLRSNFNSSDVMKTCIQGLAGSKINQLVLGEFKNERNLESFDKSVLEELCNLTLEQFRIAHFGEFPDDVSDLFNCLANASVISLLSLNLRGLEALPNDFRWQHLEVVNCKLQQFPALKFNSLKKFVFKDNKHMHTFTEINLPNLQFLDLSGNHLSFKGCCSHNEFGTTKLKHLDLSFNEIITMKSNFMGLEQLEYLDFQHSSLKQANDFSIFLSLKNLHYLDISYTNIHVVFRGIFAGLVSLQTLKMAGNSFQNNLLPDVFTDLTNLILLDLSKCQLEQVSQRAFHSLPRLQVLNMSHNRLLFLDTLPYKPLHSLRILDCSYNLIVASKEQELQHLPRSLAFLNLTKNDFSCACEHQTFLQWVKDQKQFLVGAEQMVCTQPLEMQDLPVLSFRNATCQISEAVISASVLTFLLVSVAGILVYKFYFHLLLFVGCKKYGRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLRSHAGIIFIVLQKLEKSLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLKKALLDGKPWSPEGTEDSESNQHDTTAFT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU723684
EMBL· GenBank· DDBJ
ADD84650.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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