D4IGX4 · D4IGX4_RAT

  • Protein
    Alpha-(1,6)-fucosyltransferase
  • Gene
    Fut8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

Pathway

Protein modification; protein glycosylation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi cisterna membrane
Molecular Functionglycoprotein 6-alpha-L-fucosyltransferase activity
Molecular FunctionSH3 domain binding
Biological Processfibroblast migration
Biological ProcessGDP-L-fucose metabolic process
Biological Processintegrin-mediated signaling pathway
Biological ProcessN-glycan processing
Biological Processprotein N-linked glycosylation via asparagine
Biological Processreceptor metabolic process
Biological Processregulation of cellular response to oxidative stress
Biological Processregulation of gene expression
Biological Processrespiratory gaseous exchange by respiratory system
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-(1,6)-fucosyltransferase
  • EC number
  • Alternative names
    • GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
    • GDP-fucose--glycoprotein fucosyltransferase
    • Glycoprotein 6-alpha-L-fucosyltransferase

Gene names

    • Name
      Fut8
    • Synonyms
      fut8

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Brown Norway
    • AO
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D4IGX4
  • Secondary accessions
    • A6HCC9

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus, Golgi stack membrane
; Single-pass type II membrane protein
Membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-30Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond204↔266
Disulfide bond212↔230
Disulfide bond218↔222
Disulfide bond465↔472

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for coiled coil, domain, motif, region.

TypeIDPosition(s)Description
Coiled coil43-110
Domain206-493GT23
Motif299-305SH3-binding
Region365-366Important for donor substrate binding
Domain502-563SH3

Sequence similarities

Belongs to the glycosyltransferase 23 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    575
  • Mass (Da)
    66,485
  • Last updated
    2010-05-18 v1
  • Checksum
    70C8AD0E535CE07E
MRAWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDLRRMAESLRIPEGPIDQGTATGRVRVLEEQLVKAKEQIENYKKQARNGLGKDHEILRRRIENGAKELWFFLQSELKKLKHLEGNELQRHADEILLDLGHHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKARKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWETVFRPVSETCTDRSGLSTGHWSGEVNDKNIQVVELPIVDSLHPRPPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPALLKEAKTKYSNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQIAVYPHKPRTDEEIPMEPGDIIGVAGNHWDGYSKGVNRKLGKTGLYPSYKVREKIETVKYPTYPEAEK

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q6EV76FUT8_RATFut8575
A0A8I6AAW5A0A8I6AAW5_RATFut8518

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue575

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN668936
EMBL· GenBank· DDBJ
CBJ94503.1
EMBL· GenBank· DDBJ
mRNA
FN668937
EMBL· GenBank· DDBJ
CBJ94504.1
EMBL· GenBank· DDBJ
mRNA
FN668938
EMBL· GenBank· DDBJ
CBJ94505.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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