D4HRK4 · CA12A_CONER

Function

function

Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks muscular nicotinic acetylcholine receptor (CHRNA1-CHRNB1-CHRNG-CHRND), and has no effect on neuronal receptors. It is able to totally displace [125I]-Bgtx from the Torpedo receptor with a complete inhibition in the high micromolar range. It produces a biphasic inhibition curve which fits nicely with a two-site model (Ki of 0.46 and 105 nM).

Miscellaneous

Negative results: has no effect on chimeric alpha-7 (CHRNA7), alpha-3-beta-2 (CHRNA3-CHRNB2) and alpha-4-beta-2 (CHRNA4-CHRNB2).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell postsynaptic membrane
Molecular Functionacetylcholine receptor inhibitor activity
Molecular Functiontoxin activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-conotoxin EIIA

Organism names

Accessions

  • Primary accession
    D4HRK4
  • Secondary accessions
    • D4HRK5

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant29

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, propeptide, modified residue, peptide, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
PropeptidePRO_000042288017-40
Modified residue43Pyrrolidone carboxylic acid
PeptidePRO_000042288143-58Alpha-conotoxin EIIA
Modified residue45Hydroxyproline
Disulfide bond47↔53
Disulfide bond48↔58
Modified residue58Cysteine amide

Keywords

Expression

Tissue specificity

Expressed by the venom duct.

Family & Domains

Domain

The cysteine framework is I (CC-C-C). Alpha4/4 pattern.

Sequence similarities

Belongs to the conotoxin A superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    61
  • Mass (Da)
    6,779
  • Last updated
    2013-06-26 v2
  • Checksum
    39D49248B0825395
MFIVFLLVVLATTVGSFTLDRVLEGRNAAAIDNALDQRDPKRQTPGCCWNPACVKNRCGRR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ937346
EMBL· GenBank· DDBJ
ACZ37197.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ937347
EMBL· GenBank· DDBJ
ACZ37198.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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