D4HNR5 · D4HNR5_ORENI
- Proteinphenylalanine 4-monooxygenase
- GeneTph
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids461 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
Cofactor
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | iron ion binding | |
Molecular Function | phenylalanine 4-monooxygenase activity | |
Biological Process | L-phenylalanine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namephenylalanine 4-monooxygenase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > African cichlids > Pseudocrenilabrinae > Oreochromini > Oreochromis
Accessions
- Primary accessionD4HNR5
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MDAAYKGVNGNYSPEAETGDQVPGQK | ||||||
Domain | 45-123 | ACT | ||||
Sequence: SCIFSLKEEVGALAKALRLFEEKGINLTHIESRPSRMNNEQYEFFINVDSTCSQALDEVIDCLRTQISGHVHELTRSKE | ||||||
Domain | 115-461 | Biopterin-dependent aromatic amino acid hydroxylase family profile | ||||
Sequence: VHELTRSKEKDTVPWFPNDIQDLDRFANQILSYGSELDADHPGFTDPVYRARRKEFADIAYNYRHGQSIPMVEYTEEEKATWGTVFRELKTLYPTHACREHNRVFPLLEKYCGYRPDNIPQLEDVSRFLQSCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHGSKPTYTPEPDICHELLGHVPLFADPSFAQFSQEIGLASLGAPDEYIEKLATVYWFTVEFGLCKQGSEIKAYGAGLLSSFGELEYSLTEKPKLLPFDPEKTIVQKYPITEYQPVYFVAESFEDAKEKVRKFAGTIPRPFSVRYNPYTQSIEVLDNTQQLRNLADSINSEMGKLCEALRKLE |
Sequence similarities
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length461
- Mass (Da)52,661
- Last updated2010-05-18 v1
- Checksum4E056C27F09E6D33
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ800839 EMBL· GenBank· DDBJ | ACX55860.1 EMBL· GenBank· DDBJ | mRNA |