D4GZF9 · D4GZF9_HALVD
- ProteinL-lactate dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids320 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the reversible oxidation of malate to oxaloacetate.
Catalytic activity
- (S)-lactate + NAD+ = pyruvate + NADH + H+
Pathway
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 14-20 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 40 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 100 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 124-126 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 181 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-lactate dehydrogenase activity | |
Biological Process | lactate metabolic process | |
Biological Process | pyruvate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Methanobacteriati > Methanobacteriota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax
Accessions
- Primary accessionD4GZF9
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 10-148 | Lactate/malate dehydrogenase N-terminal | |||
Domain | 151-315 | Lactate/malate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the LDH/MDH superfamily. LDH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length320
- Mass (Da)34,569
- Last updated2010-05-18 v1
- MD5 ChecksumD9E0071F1A72720CEDD61CB651D29D8E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001956 EMBL· GenBank· DDBJ | ADE03075.1 EMBL· GenBank· DDBJ | Genomic DNA |