D4GYG6 · AGLQ_HALVD
- ProteinArchaeal glycosylation protein Q
- GeneaglQ
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids371 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Putative isomerase involved in the N-glycosylation pathway. Required for the appearance of the methyl ester of hexuronic acid found at position four of the pentasaccharide N-linked to the S-layer glycoprotein. Either involved in preparing the third sugar for attachment of the fourth pentasaccharide subunit or processing the fourth sugar prior to its addition to the lipid-linked trisaccharide.
Pathway
Cell surface structure biogenesis; S-layer biogenesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | carbohydrate metabolic process | |
Biological Process | S-layer organization |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArchaeal glycosylation protein Q
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax
Accessions
- Primary accessionD4GYG6
- Secondary accessions
Proteomes
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Defects in N-glycosylation pathway, characterized by impaired addition of the fourth sugar of the pentasaccharide: both dolichol phosphate, the lipid carrier used in H.volcanii N-glycosylation, and modified S-layer glycoprotein Asn residues only present the first three subunits of the pentasaccharide.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 34 | No effect. | ||||
Sequence: H → D | ||||||
Mutagenesis | 37 | No effect. | ||||
Sequence: E → A | ||||||
Mutagenesis | 38 | Defects in N-glycosylation pathway. | ||||
Sequence: T → L | ||||||
Mutagenesis | 50 | No effect. | ||||
Sequence: F → A | ||||||
Mutagenesis | 52 | Defects in N-glycosylation pathway. | ||||
Sequence: K → L | ||||||
Mutagenesis | 55 | No effect. | ||||
Sequence: E → K | ||||||
Mutagenesis | 58 | No effect. | ||||
Sequence: D → A | ||||||
Mutagenesis | 59 | No effect. | ||||
Sequence: E → A | ||||||
Mutagenesis | 61 | No effect. | ||||
Sequence: R → D | ||||||
Mutagenesis | 66 | No effect. | ||||
Sequence: A → Q | ||||||
Mutagenesis | 81 | No effect. | ||||
Sequence: H → D | ||||||
Mutagenesis | 93 | No effect. | ||||
Sequence: K → A | ||||||
Mutagenesis | 104 | No effect. | ||||
Sequence: W → A | ||||||
Mutagenesis | 114 | No effect. | ||||
Sequence: R → D | ||||||
Mutagenesis | 118 | No effect. | ||||
Sequence: N → A | ||||||
Mutagenesis | 187 | No effect. | ||||
Sequence: D → K |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000428767 | 1-371 | Archaeal glycosylation protein Q | |||
Sequence: MTSLSDILASSAEAGLSLQRSDGSMPAGHNGPYHDPETPVRNTSHWLVTFLKAHELTDENRFRQAASDAVSYLLSEEARPHGHTFEHRQNDTKDRCNGLMGQAWSLEALALAARALDNERAAAVAADVFLSHPFCDKLKLWQRVDTDGTILGFDRTFNHQLWFAASGGLVAHTAPQEVSQRVRDFLDSLPSTIDLYENGLIRHPLRPSMDLSELAESVTHDVHRSMVRNHLLHYLRPPRSKRRLRNKAEGYHSFNLYALAILAREFPSHSVWSTDLLSDILEYTLSEEFREATTDNKFSHPYNPPGFEVPAAMETFSVGSYKEREMWVNEQIQHSFDPNTSLLTRGTDDKQTHAARLYEATRLDDYEIYLD |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length371
- Mass (Da)42,133
- Last updated2010-05-18 v1
- Checksum563A742EEABEF171
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FM955370 EMBL· GenBank· DDBJ | CAW30728.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP001956 EMBL· GenBank· DDBJ | ADE02297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AOHU01000027 EMBL· GenBank· DDBJ | ELY35857.1 EMBL· GenBank· DDBJ | Genomic DNA |