D4GYE3 · PTHP_HALVD

Function

function

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain (By similarity).
Is involved in fructose transport

Miscellaneous

PTS-type transport systems are very rare in archaea.

Activity regulation

Phosphorylation on Ser-47 inhibits the phosphoryl transfer from enzyme I to HPr.

Features

Showing features for active site.

1891020304050607080
MERTVTVVPEDGLHARPASKFVETANKFDADVQLGRADEDDLVPAASMLAVTGLGVGHDESVRLVAEGDDAEAALDALEDILSTPEAKQ
TypeIDPosition(s)Description
Active site14Pros-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Biological Processphosphoenolpyruvate-dependent sugar phosphotransferase system

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphocarrier protein HPr

Gene names

    • Name
      ptsH1
    • ORF names
      C498_11246
    • Ordered locus names
      HVO_1497

Organism names

Accessions

  • Primary accession
    D4GYE3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004289861-89Phosphocarrier protein HPr
Modified residue47Phosphoserine; by HPrK/P

Keywords

Proteomic databases

Expression

Induction

Expression is highly up-regulated in presence of fructose.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-89HPr

Sequence similarities

Belongs to the HPr family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    89
  • Mass (Da)
    9,359
  • Last updated
    2010-05-18 v1
  • Checksum
    7A0B355161D7117E
MERTVTVVPEDGLHARPASKFVETANKFDADVQLGRADEDDLVPAASMLAVTGLGVGHDESVRLVAEGDDAEAALDALEDILSTPEAKQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001956
EMBL· GenBank· DDBJ
ADE03675.1
EMBL· GenBank· DDBJ
Genomic DNA
AOHU01000090
EMBL· GenBank· DDBJ
ELY28265.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp