D4GYE3 · PTHP_HALVD
- ProteinPhosphocarrier protein HPr
- GeneptsH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain (By similarity).
Is involved in fructose transport
Is involved in fructose transport
Miscellaneous
PTS-type transport systems are very rare in archaea.
Activity regulation
Phosphorylation on Ser-47 inhibits the phosphoryl transfer from enzyme I to HPr.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 14 | Pros-phosphohistidine intermediate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePhosphocarrier protein HPr
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax
Accessions
- Primary accessionD4GYE3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000428986 | 1-89 | Phosphocarrier protein HPr | |||
Sequence: MERTVTVVPEDGLHARPASKFVETANKFDADVQLGRADEDDLVPAASMLAVTGLGVGHDESVRLVAEGDDAEAALDALEDILSTPEAKQ | ||||||
Modified residue | 47 | Phosphoserine; by HPrK/P | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Induction
Expression is highly up-regulated in presence of fructose.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-89 | HPr | ||||
Sequence: MERTVTVVPEDGLHARPASKFVETANKFDADVQLGRADEDDLVPAASMLAVTGLGVGHDESVRLVAEGDDAEAALDALEDILSTPEAKQ |
Sequence similarities
Belongs to the HPr family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length89
- Mass (Da)9,359
- Last updated2010-05-18 v1
- Checksum7A0B355161D7117E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001956 EMBL· GenBank· DDBJ | ADE03675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AOHU01000090 EMBL· GenBank· DDBJ | ELY28265.1 EMBL· GenBank· DDBJ | Genomic DNA |