D4GWY2 · FLGA2_HALVD

Function

function

Flagellin that plays both structural and regulatory roles in flagella biosynthesis. Does not constitute a major flagellin in terms of abundance contrary to FlgA1: may regulate the flagella-dependent swimming motility depending on the relative abundance of FlgA1. Not involved in PibD-dependent surface adhesion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentarchaeal-type flagellum
Molecular Functionstructural molecule activity
Biological Processarchaeal or bacterial-type flagellum-dependent cell motility

Names & Taxonomy

Protein names

  • Recommended name
    Flagellin A2

Gene names

    • Name
      flgA2
    • ORF names
      C498_12693
    • Ordered locus names
      HVO_1211

Organism names

Accessions

  • Primary accession
    D4GWY2
  • Secondary accessions
    • L9UTC9

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Straight flagella, mainly at the poles (PubMed:10632878).
Cells lacking flgA2 but not flgA1 are hypermotile, display an increased number of flagella per cell, as well as an increased flagellum length (PubMed:23989184).
Cells lacking both flgA1 and flgA2 show defects in motility, whitout affecting surface adhesion ability (PubMed:20363933).

PTM/Processing

Features

Showing features for propeptide, chain, glycosylation.

TypeIDPosition(s)Description
PropeptidePRO_00004290551-11
ChainPRO_00004290541-220Flagellin A2
Glycosylation78N-linked (GlcNAc...) asparagine
Glycosylation95N-linked (GlcNAc...) asparagine
Glycosylation112N-linked (GlcNAc...) asparagine
Glycosylation124N-linked (GlcNAc...) asparagine

Post-translational modification

Glycosylated by a pentasaccharide similar to the S-layer glycoprotein, probably comprising a hexose, 2 hexuronic acids, a methyl ester of a hexuronic acid and mannose.

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the archaeal flagellin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    220
  • Mass (Da)
    22,810
  • Last updated
    2010-05-18 v1
  • Checksum
    8F87AC8E05F80C90
MFNNITDDDRGQVGIGTLIVFIAMVLVAAIAAGVLVNTAGFLQATAEDAGEQSVNKVTNRVEVLNTHGTVGGEEDIDNITLTVRLAAGSDAVDMNETSIKYLSGDSVVTLTNQTVTSGANSATNDSAEGVADSDEFGLSEVTDDDGSFGVLNSMNDRYEVTIDTAAIETSDGDNTNLIGGLSTGEQVTLEITSRTGGTTQVILTMPQQLAGKTQNEPVEL

Sequence caution

The sequence ELY28104.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001956
EMBL· GenBank· DDBJ
ADE03249.1
EMBL· GenBank· DDBJ
Genomic DNA
AOHU01000091
EMBL· GenBank· DDBJ
ELY28104.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp