D4DX30 · D4DX30_SEROD

Function

function

Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate acid metabolism; galactarate degradation; D-glycerate from galactarate: step 2/3.

Features

Showing features for active site, site, binding site.

TypeIDPosition(s)Description
Active site68Proton acceptor
Site93Transition state stabilizer
Site107Increases basicity of active site His
Binding site169substrate
Binding site171Mg2+ (UniProtKB | ChEBI)
Binding site197Mg2+ (UniProtKB | ChEBI)
Binding site197substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2-dehydro-3-deoxyglucarate aldolase activity
Molecular Functionmagnesium ion binding
Biological ProcessD-glucarate catabolic process
Biological Processgalactarate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-keto-4-deoxy-D-glucarate aldolase
  • EC number
  • Short names
    KDGluc aldolase
    ; KDGlucA
  • Alternative names
    • 2-dehydro-3-deoxy-D-glucarate aldolase
    • 2-keto-3-deoxy-D-glucarate aldolase
    • 5-dehydro-4-deoxy-D-glucarate aldolase
    • Alpha-keto-beta-deoxy-D-glucarate aldolase

Gene names

    • Name
      garL
    • ORF names
      HMPREF0758_0480

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 4582
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Serratia

Accessions

  • Primary accession
    D4DX30

Proteomes

Subcellular Location

Interaction

Subunit

Homohexamer; trimer of dimers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-264HpcH/HpaI aldolase/citrate lyase

Sequence similarities

Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    29,588
  • Last updated
    2010-05-18 v1
  • Checksum
    7A71B15B9A6E04BE
MPGALIADAFLPQRKIQGNAMKSCHNRFRQSLQQGETLIGCWSALGNPISTEVLGLAGFDWLVLDGEHAPNDITTFVPQLMALKGSDSAAVVRPPCNEPVIIKRLLDIGFHNFLIPFVESEQQALQAVASTRYPPAGIRGVSVSHRSNGYGTVADYFATINDNVSVLVQIETQAGVDNLDAIAAVDGVDGIFVGPGDLSAALGYLGQPNHPEVQAVIRHIFDRAKTAGKPSGILAPAEADARRYLQWGAQFVAVGSDLGVLRNATQALCDRFKTSEK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ADBY01000014
EMBL· GenBank· DDBJ
EFE97896.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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