D4DKZ0 · D4DKZ0_TRIVH
- Protein4-trimethylaminobutyraldehyde dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids514 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Catalytic activity
- (5-hydroxyindol-3-yl)acetaldehyde + NAD+ + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H+
- 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + 2 H+
- pentanal + NAD+ + H2O = pentanoate + NADH + 2 H+
- propanal + NAD+ + H2O = propanoate + NADH + 2 H+
- spermine monoaldehyde + NAD+ + H2O = N-(2-carboxyethyl)spermidine + NADH + 2 H+
- hexanal + NAD+ + H2O = hexanoate + NADH + 2 H+
- imidazole-4-acetaldehyde + NAD+ + H2O = imidazole-4-acetate + NADH + 2 H+
- acrolein + NAD+ + H2O = acrylate + NADH + 2 H+
- butanal + NAD+ + H2O = butanoate + NADH + 2 H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 266 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aldehyde dehydrogenase (NAD+) activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-trimethylaminobutyraldehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton
Accessions
- Primary accessionD4DKZ0
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 33-498 | Aldehyde dehydrogenase | ||||
Sequence: TSNKTFQSVNPATEEVLADVGVASSADVDQAVKAAQKAFPAWSRTPHVARARILLKAVQLLRERNDEIARVETADTGKPFSETSTVDVTTGADVLEYFASMVAGGGLNGETVQLRDDAWVYTKKAPLGVCAGIGAWNYPIQIALWKSAPCLAAGNTMVYKPSEFTPLHGEILADLYTQAGLPAGVFNVVHGAGDVGAYLTAHPAIAKVSFTGQVATGKKVAGSAAGGMKYVTMELGGKSPFIVLPDADLDSAVDGAILANFFSTGQVCTNGTRVFVPSSLKADFESLLLKKMQYVRAGDVMDPATNFGPLVSDVHYKKVTDYIRHGVEQDKAKLLYGGLEKPKASSPSASFDKGYWITPTIFTDCRDEMKIVQEEIFGPVMSILYYETVDEVVRRANETPLGLAAGVFTQNINLAHRVVDQLEAGITWINSWGESPAEMSVGGWKQSGVGVENGRRGIEAWVRTKS |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length514
- Mass (Da)55,168
- Last updated2010-05-18 v1
- Checksum02F56D27A309B937
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ACYE01000484 EMBL· GenBank· DDBJ | EFE37523.1 EMBL· GenBank· DDBJ | Genomic DNA |