D4DGQ3 · D4DGQ3_TRIVH
- ProteinLysophospholipase NTE1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1453 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.
Catalytic activity
- a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 1183 | Nucleophile | |||
Active site | 1301 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | lysophospholipase activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylcholine metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysophospholipase NTE1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton
Accessions
- Primary accessionD4DGQ3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 19-39 | Helical | |||
Transmembrane | 46-67 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 170-194 | Disordered | |||
Region | 227-312 | Disordered | |||
Compositional bias | 276-305 | Polar residues | |||
Region | 411-471 | Disordered | |||
Region | 506-525 | Disordered | |||
Domain | 632-668 | Cyclic nucleotide-binding | |||
Region | 691-710 | Disordered | |||
Domain | 772-874 | Cyclic nucleotide-binding | |||
Domain | 1150-1314 | PNPLA | |||
Motif | 1154-1159 | GXGXXG | |||
Motif | 1181-1185 | GXSXG | |||
Motif | 1301-1303 | DGA/G | |||
Compositional bias | 1431-1445 | Basic and acidic residues | |||
Region | 1431-1453 | Disordered | |||
Sequence similarities
Belongs to the NTE family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,453
- Mass (Da)160,513
- Last updated2010-05-18 v1
- Checksum88C15DBE698BCCBA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 276-305 | Polar residues | |||
Compositional bias | 1431-1445 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ACYE01000361 EMBL· GenBank· DDBJ | EFE38995.1 EMBL· GenBank· DDBJ | Genomic DNA |