D4DGQ3 · D4DGQ3_TRIVH

Function

function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for active site.

114532004006008001,0001,2001,400
TypeIDPosition(s)Description
Active site1183Nucleophile
Active site1301Proton acceptor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionlysophospholipase activity
Biological Processlipid catabolic process
Biological Processphosphatidylcholine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysophospholipase NTE1
  • EC number
  • Alternative names
    • Intracellular phospholipase B

Gene names

    • ORF names
      TRV_06358

Organism names

  • Taxonomic identifier
  • Strain
    • HKI 0517
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton

Accessions

  • Primary accession
    D4DGQ3

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane19-39Helical
Transmembrane46-67Helical

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain, motif.

Type
IDPosition(s)Description
Region170-194Disordered
Region227-312Disordered
Compositional bias276-305Polar residues
Region411-471Disordered
Region506-525Disordered
Domain632-668Cyclic nucleotide-binding
Region691-710Disordered
Domain772-874Cyclic nucleotide-binding
Domain1150-1314PNPLA
Motif1154-1159GXGXXG
Motif1181-1185GXSXG
Motif1301-1303DGA/G
Compositional bias1431-1445Basic and acidic residues
Region1431-1453Disordered

Sequence similarities

Belongs to the NTE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,453
  • Mass (Da)
    160,513
  • Last updated
    2010-05-18 v1
  • Checksum
    88C15DBE698BCCBA
MADFAGTIFLFFVQVLPGLLYSVITFTTITVPTALFTLFSMSLTFTMNFTTLLLITLFLVSTISWFVRYRFLNMYAHLPPEPQRQEPQIDLFPDTQEGDSKPGLANYLDEFLSAIKVFGYLERPVFHELTRTMQTRKLIAGETLLLEEEKGFCLVVDGLVQIFVKSARERGKDGESSVEDSMEEEEEQHHRHHQGYQLLTEVKNGASMSSLFSILSLFSEDVKLRYQEGEEPASPSPVSPSPFASSPRSSFQDRHHHHRDISLPSNGGRLPTVPPMTLDDTNSAAHFSTAHTPPTSSAQNRRTPKRPRTNSVHPDIVARAVVDTTIAIIPASAFRRLTRLYPRATAHIIQVILTRLQRVTFATAHSYLGLTTDVLSIEKKMNKFTSFDLPNDLRGAPLDRLKQKFQRAVQRLGPEEGSKGIALHNPGVSNRRRSSSSLRKDASLRAKASAANGQATSPPTPPITDKEAAGVSPGDLLSTIQLSRFGPRHGIDRRLASRSILLDSTSTSGIKTPMHTSPDASSPANSIFNSPSTVHVNEDSLFRESILDCMVKALGLTATTREALPLPKGFGSADGSPHLVSYDSRKQKAVFNNAFGYIDPYEAFGDGDSESQMSISVTSAGGTPPVANLKAELSNEIEIVYFPKGSVLVEQGERNPGLYYVIDGFLDVGIPVNDKGEDLIGPSKSNIHSEPLLPLRRPSNVNAQNQRKKTSRRSLYMVKPGDLEGYIGSITSYRSFTDVTAKTDVYVGFLPRICLERIADRYPLVLLSMAKRLTNVLPRLLLHIDFALEWVQVNAGQVIYHQGDESDSIYIVLNGRLRSVLESGDNKVSVVGEHGQGESVGELEVMTETTRPATLHAIRDTELAKFPRSLFNSLAQEHPGITIQVSKLVAQRMKHLINTKLLEAGGEKAHDEASSLTSTLNLRTVAILPVTSGIPVVEFASRLLSAFNQIGVPDGVASLHQADIFNHLGRHAFNRMGKLKLSQYLADLEERYGMLIYVADTSVNAPWTQTCISQADCILLVGVAGASPSIGEYERFLLGMKTTARKELVLLHAERYSPPGLTRQWLKNRMWINGGHHHIQMTYRATPEPALPQIKKFGTVLKQRVQVIQAEIQKYTSRRIRQEPLYSATTPFKGDFHRLARRLCGKSVGLVLGGGGARGIAHIGVITALEEAGIPIDIVGGTSIGAFIGALYARDADVVPMYGRAKKFAAKMGSIWRFALDLTYPSVSYTTGHEFNRGLFKAFTDSQIEDSWLEFYCNTTNISQSRSDYHSSGYVWRYVRASMSLAGLLPPLCDEGSLLLDGGYVDNLTVSRMKSLGADVIFAVDVGAIDDNTPQVYGDSLSGFWTVLNRWNPFTSVPNPPTLSEIQARLAYVSSVGALERAKNTPGCLYMRPPIDCYGTLEFGKFDEIYQVGYQYGKGFLEKLRKEGSLPMPEETEEKKNMRRTMAPRRASI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias276-305Polar residues
Compositional bias1431-1445Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ACYE01000361
EMBL· GenBank· DDBJ
EFE38995.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help