D4AV26 · MNS1B_ARTBC

Function

function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Ca2+. Can also use Mg2+, but with lower efficiency.

Pathway

Protein modification; protein glycosylation.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site374Proton donor
Binding site500Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular region
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Biological Processcarbohydrate metabolic process
Biological ProcessERAD pathway
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable mannosyl-oligosaccharide alpha-1,2-mannosidase ARB_00035
  • EC number
  • Alternative names
    • Class I alpha-mannosidase
    • Man(9)-alpha-mannosidase

Gene names

    • ORF names
      ARB_00035

Organism names

Accessions

  • Primary accession
    D4AV26

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_500305352419-509Probable mannosyl-oligosaccharide alpha-1,2-mannosidase ARB_00035
Glycosylation170N-linked (GlcNAc...) asparagine
Disulfide bond331↔360
Glycosylation399N-linked (GlcNAc...) asparagine

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    509
  • Mass (Da)
    56,291
  • Last updated
    2010-05-18 v1
  • Checksum
    46EE8725BBCD8015
MKSLSLLGVSSLALTSLALPTMNQNQHRFVALADLADEDKPQAIKDAFNHAWKGYMTHAYPMDELRPVSNEGSNPLNGWGATPVDALSTAIIMGLPDVVNQILDHISKIDFSKTDDLCSLFETTIRYLGGLISGYDLLKNSGAMNADPEKVDVLLKKAVELADVLKFSFNSTTGIPSNTLNIPKQTTDGATSNGLATVGTLVLEWTRLSDLTNKEEYGKLAQKAEEYLLNPQPKSNEVFPGLVGGSINIQTGKFERASASWEGGDDSFYEYLIKMYVYDRSAFGKYKDRWVLAAQSTIEHLKSSPLLHPDTTFVGAWANGALVKSSQHLACFDGGNFILGGRELNRPEFTRFGLKLVDGCHKTYANTVTKIGPESFGWDEKNVPSDQASFFTKSGFYINSSGYVLRPEVIESFYYAYRVTGDKKYQRWIWDAFVAISETTKTDSGFSSISDVNAAKGGSKTDSQPSFFFAETLKYTYLAFSDEADWQISRSGKDKFVFNTEAHPIRVRN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ABSU01000012
EMBL· GenBank· DDBJ
EFE32948.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp