D4AFW2 · D4AFW2_9APIC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 30164
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    D4AFW2

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-40Helical
Transmembrane60-88Helical
Transmembrane108-128Helical
Transmembrane148-172Helical
Transmembrane193-217Helical
Transmembrane250-267Helical
Transmembrane279-297Helical
Transmembrane309-334Helical
Transmembrane346-366Helical
Transmembrane378-397Helical
Transmembrane418-438Helical
Transmembrane458-476Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-477Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    477
  • Mass (Da)
    52,973
  • Last updated
    2010-05-18 v1
  • Checksum
    2B84B3759F8B37D3
FFVFNRYTLITNCNHKTLGLYYLWFSFLFGSYGFLLSVILRTELYSSSLRIIAQENVNLYNMIFTLHGIIMIFFNIMPGLFGGFGNYFLPILCGSPELAYPRINSISLLLQPIAFILVILSTAAEFGGGTGWTLYPPLSTSLMSLSPVAVDVIIVGLLVSGIASIMSSLNFITTVMHLRSKGLTLGILSVSTWSLIITSVMLLLTLPVLTGGVLMLLSDLHFNTLFFDPTFAGDPILYQHLFWFFGHPEVYILILPAFGVISHVISTNYCRSLFGNQSMILAMSCIAILGSVVWAHHMYTTGLEVDTRAFFTSTTILISIPTGTKIFNWICTYMGSNFGITHSSSLLSLLFICTFTFGGTTGVILGNAAIDIALHDTYYVIAHFHFVLSIGAIIGLFTLASSFQENFFGKHLRENSIIILWSILFFIGVVLTFLPMHFLGFNVMPRRIPDYPDALNGWNMICSIGSTMTLFGLFIFK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB444132
EMBL· GenBank· DDBJ
BAI82337.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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