D4ADX7 · KCNF1_RAT
- ProteinVoltage-gated potassium channel regulatory subunit KCNF1
- GeneKcnf1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids493 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization (PubMed:9305895, PubMed:9696692).
Accelerates inactivation but has relatively little effect on deactivation (PubMed:9696692).
Coexpression with KCNB1 or KCNB2 markedly slows inactivation (PubMed:9305895).
Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process (PubMed:9305895).
The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit (PubMed:9305895, PubMed:9696692).
Fails to produce a potassium current when expressed alone (PubMed:9305895).
Accelerates inactivation but has relatively little effect on deactivation (PubMed:9696692).
Coexpression with KCNB1 or KCNB2 markedly slows inactivation (PubMed:9305895).
Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process (PubMed:9305895).
The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit (PubMed:9305895, PubMed:9696692).
Fails to produce a potassium current when expressed alone (PubMed:9305895).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | ciliary base | |
Cellular Component | membrane | |
Cellular Component | voltage-gated potassium channel complex | |
Molecular Function | potassium channel regulator activity | |
Molecular Function | voltage-gated potassium channel activity | |
Biological Process | action potential | |
Biological Process | non-motile cilium assembly | |
Biological Process | potassium ion transmembrane transport | |
Biological Process | potassium ion transport | |
Biological Process | protein homooligomerization | |
Biological Process | regulation of potassium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVoltage-gated potassium channel regulatory subunit KCNF1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionD4ADX7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-183 | Cytoplasmic | ||||
Sequence: MDASAEQSLPEPGSQDSVAGDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARV | ||||||
Transmembrane | 184-204 | Helical; Name=Segment S1 | ||||
Sequence: VAVLSFLLILVSSVVMCMGTI | ||||||
Topological domain | 205-223 | Extracellular | ||||
Sequence: PELQVVDSEGNRVEHPTLE | ||||||
Transmembrane | 224-244 | Helical; Name=Segment S2 | ||||
Sequence: NVETACIGWFTLEYLLRLFSS | ||||||
Topological domain | 245-249 | Cytoplasmic | ||||
Sequence: PNKLH | ||||||
Transmembrane | 250-270 | Helical; Name=Segment S3 | ||||
Sequence: FALSFMNIVDVLAILPFYVSL | ||||||
Topological domain | 271-289 | Extracellular | ||||
Sequence: TLTHLGARMMELTNVQQAV | ||||||
Transmembrane | 290-310 | Helical; Voltage-sensor; Name=Segment S4 | ||||
Sequence: QALRIMRIARIFKLARHSSGL | ||||||
Topological domain | 311-324 | Cytoplasmic | ||||
Sequence: QTLTYALKRSFKEL | ||||||
Transmembrane | 325-345 | Helical; Name=Segment S5 | ||||
Sequence: GLLLMYLAVGIFVFSALGYTM | ||||||
Topological domain | 346-357 | Extracellular | ||||
Sequence: EQSHPETLFKSI | ||||||
Intramembrane | 358-378 | Pore-forming; Name=Segment H5 | ||||
Sequence: PQSFWWAIITMTTVGYGDIYP | ||||||
Topological domain | 379-385 | Extracellular | ||||
Sequence: KTTLGKL | ||||||
Transmembrane | 386-406 | Helical; Name=Segment S6 | ||||
Sequence: NAAISFLCGVIAIALPIHPII | ||||||
Topological domain | 407-493 | Cytoplasmic | ||||
Sequence: NNFVRYYNKQRVLETAAKHELELMELNSSSAESKPGGSRSDLDTLPPEPAAREGPSWGSRLKLSHSDTFIPLLTEEKHHRTRLQSCK |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000460743 | 1-493 | Voltage-gated potassium channel regulatory subunit KCNF1 | |||
Sequence: MDASAEQSLPEPGSQDSVAGDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSAESKPGGSRSDLDTLPPEPAAREGPSWGSRLKLSHSDTFIPLLTEEKHHRTRLQSCK |
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 370-375 | Selectivity filter | ||||
Sequence: TVGYGD |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length493
- Mass (Da)55,663
- Last updated2024-10-02 v3
- Checksum7663775B6D43D317
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 154-155 | in Ref. 1; M81783 | ||||
Sequence: VD → SS | ||||||
Sequence conflict | 239 | in Ref. 1; M81783 | ||||
Sequence: L → V | ||||||
Sequence conflict | 349 | in Ref. 1; M81783 | ||||
Sequence: H → Q | ||||||
Sequence conflict | 443 | in Ref. 1; M81783 | ||||
Sequence: G → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M81783 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AABR07063695 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |