D4ADX7 · KCNF1_RAT

  • Protein
    Voltage-gated potassium channel regulatory subunit KCNF1
  • Gene
    Kcnf1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization (PubMed:9305895, PubMed:9696692).
Accelerates inactivation but has relatively little effect on deactivation (PubMed:9696692).
Coexpression with KCNB1 or KCNB2 markedly slows inactivation (PubMed:9305895).
Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process (PubMed:9305895).
The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit (PubMed:9305895, PubMed:9696692).
Fails to produce a potassium current when expressed alone (PubMed:9305895).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentciliary base
Cellular Componentmembrane
Cellular Componentvoltage-gated potassium channel complex
Molecular Functionpotassium channel regulator activity
Molecular Functionvoltage-gated potassium channel activity
Biological Processaction potential
Biological Processnon-motile cilium assembly
Biological Processpotassium ion transmembrane transport
Biological Processpotassium ion transport
Biological Processprotein homooligomerization
Biological Processregulation of potassium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-gated potassium channel regulatory subunit KCNF1
  • Alternative names
    • Potassium voltage-gated channel subfamily F member 1
    • Voltage-gated potassium channel subunit Kv5.1

Gene names

    • Name
      Kcnf1

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D4ADX7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane, intramembrane.

TypeIDPosition(s)Description
Topological domain1-183Cytoplasmic
Transmembrane184-204Helical; Name=Segment S1
Topological domain205-223Extracellular
Transmembrane224-244Helical; Name=Segment S2
Topological domain245-249Cytoplasmic
Transmembrane250-270Helical; Name=Segment S3
Topological domain271-289Extracellular
Transmembrane290-310Helical; Voltage-sensor; Name=Segment S4
Topological domain311-324Cytoplasmic
Transmembrane325-345Helical; Name=Segment S5
Topological domain346-357Extracellular
Intramembrane358-378Pore-forming; Name=Segment H5
Topological domain379-385Extracellular
Transmembrane386-406Helical; Name=Segment S6
Topological domain407-493Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004607431-493Voltage-gated potassium channel regulatory subunit KCNF1

Proteomic databases

Expression

Tissue specificity

Expressed in brain namely in the piriform cortex, olfactory tubercle, and medial habenular nucleus (PubMed:1740690).
Also expressed in the medial amygdaloid nuclei and the lateral amygdaloid area (PubMed:1740690).

Gene expression databases

Interaction

Subunit

Heterotetramer with KCNB1 or KCNB2.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif370-375Selectivity filter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    493
  • Mass (Da)
    55,663
  • Last updated
    2024-10-02 v3
  • Checksum
    7663775B6D43D317
MDASAEQSLPEPGSQDSVAGDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVVDSEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSAESKPGGSRSDLDTLPPEPAAREGPSWGSRLKLSHSDTFIPLLTEEKHHRTRLQSCK

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict154-155in Ref. 1; M81783
Sequence conflict239in Ref. 1; M81783
Sequence conflict349in Ref. 1; M81783
Sequence conflict443in Ref. 1; M81783

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M81783
EMBL· GenBank· DDBJ
-mRNA No translation available.
AABR07063695
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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