D4AB34 · ERFE_RAT

Function

function

Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (By similarity).
Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773).
Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (PubMed:30566056).
Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (PubMed:24187137).
Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity).
The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity).

Features

Showing features for site.

134150100150200250300
TypeIDPosition(s)Description
Site320Required for correct protein folding in the endoplasmic reticulum

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functionhormone activity
Molecular Functionidentical protein binding
Biological Processestablishment of localization in cell
Biological Processfatty acid transport
Biological Processintracellular iron ion homeostasis
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of autophagy
Biological Processnegative regulation of gluconeogenesis
Biological Processnegative regulation of osteoblast differentiation
Biological Processnegative regulation of osteoclast differentiation
Biological Processpositive regulation of fatty acid transport
Biological Processpositive regulation of glucose import
Biological Processpositive regulation of insulin receptor signaling pathway
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processregulation of fatty acid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Erythroferrone
  • Alternative names
    • Complement C1q tumor necrosis factor-related protein 15
    • Myonectin

Gene names

    • Name
      Erfe
    • Synonyms
      C1qtnf15, Ctrp15
      , Fam132b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D4AB34

Proteomes

Organism-specific databases

Subcellular Location

Secreted
Note: Secreted when glycosylated at Asn-230 and Asn-282 (By similarity).
Hydroxylation promotes secretion (By similarity).

Keywords

PTM/Processing

Features

Showing features for signal, chain, modified residue, glycosylation.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000042212225-341Erythroferrone
Modified residue101Hydroxyproline
Modified residue103Hydroxyproline
Modified residue104Hydroxyproline
Modified residue106Hydroxyproline
Modified residue107Hydroxyproline
Modified residue109Hydroxyproline
Glycosylation230N-linked (GlcNAc...) asparagine
Glycosylation282N-linked (GlcNAc...) asparagine
Glycosylation293N-linked (GlcNAc...) asparagine
Glycosylation320N-linked (GlcNAc...) asparagine

Post-translational modification

N-glycosylated; required for secretion of the mature protein.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer; disulfide-linked (By similarity).
Forms trimer, hexamers and higher molecular weight oligomers (By similarity).
May form heteromeric complexes with C1QTNF2 and C1QTNF12 and, to a lesser extent, with C1QTNF5 and C1QTNF10 (By similarity).
Interacts with BMP5 and BMP7; the interaction inhibits BMP-induced transcription of HAMP (By similarity).
Interacts with BMP6; the interaction inhibits BMP-induced transcription of HAMP (By similarity).
Interacts with BMP2 (By similarity).
Interacts with heterodimers composed of BMP2 and BMP6 in vitro, the interaction inhibits the heterodimer binding to its receptor BMPR1A/ALK3 and thereby suppresses expression of HAMP (By similarity).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region30-65Disordered
Compositional bias43-57Pro residues
Region78-115Disordered
Compositional bias100-115Pro residues
Region137-165Disordered
Compositional bias145-165Polar residues
Domain186-341C1q

Sequence similarities

Belongs to the adipolin/erythroferrone family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    341
  • Mass (Da)
    36,369
  • Last updated
    2010-04-20 v1
  • Checksum
    9467635C8DEFDBBD
MASTRSPGGARTLLACASLLAAMGLGVPESAEPVGTQARPQPPGTELPAPPAHSPPEPTIAHAHSVDPRDAWMLFVKQSDKGINSKKRSRTKARRLKLGLPGPPGPPGPQGPPGPFIPSEVLLKEFQLLLKGAVRQRESTEHCTRDLTTPASGGPSRDPVTQELESQDQGAVLALLAATLAQSPRAPRVEAAFHCRLRRDVQVERRALHELGVYYLPEVEGAFRRGPGLNLTSGQYTAPVAGFYALAATLHVALTKQPRKGPPQPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQTGHYTSVFLDNASGSSLTVRGGSHFSAILLGL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias43-57Pro residues
Compositional bias100-115Pro residues
Compositional bias145-165Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH473997
EMBL· GenBank· DDBJ
EDL92028.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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