D4AAT1 · D4AAT1_RAT

  • Protein
    ADAM metallopeptidase with thrombospondin type 1 motif, 8
  • Gene
    Adamts8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1905100200300400500600700800900
Type
IDPosition(s)Description
Binding site237Ca2+ 1 (UniProtKB | ChEBI)
Binding site237Ca2+ 2 (UniProtKB | ChEBI)
Binding site320Ca2+ 1 (UniProtKB | ChEBI)
Binding site320Ca2+ 2 (UniProtKB | ChEBI)
Binding site327Ca2+ 1 (UniProtKB | ChEBI)
Binding site378Zn2+ (UniProtKB | ChEBI); catalytic
Active site379
Binding site382Zn2+ (UniProtKB | ChEBI); catalytic
Binding site388Zn2+ (UniProtKB | ChEBI); catalytic
Binding site439Ca2+ 1 (UniProtKB | ChEBI)
Binding site442Ca2+ 2 (UniProtKB | ChEBI)
Binding site442Ca2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processextracellular matrix organization
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase with thrombospondin type 1 motif, 8

Gene names

    • Name
      Adamts8

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D4AAT1

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-28
ChainPRO_503517906029-905
Disulfide bond309↔362
Disulfide bond338↔344
Disulfide bond356↔439
Disulfide bond394↔423
Disulfide bond467↔492
Disulfide bond478↔502
Disulfide bond487↔523
Disulfide bond517↔528
Disulfide bond554↔591
Disulfide bond558↔596
Disulfide bond569↔581

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region139-163Disordered
Region183-223Disordered
Compositional bias185-218Basic and acidic residues
Domain234-444Peptidase M12B

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    905
  • Mass (Da)
    99,271
  • Last updated
    2022-05-25 v4
  • Checksum
    C7B5F91D63288C2D
MLRDPTATRWPPLLLLLLQLPPPPLVCGAPARPGTRTQASELVVPTRLPSSASELAFHLSAFGQSFVLRLAPDASFLAPEFKIERLGGSSAAAGGEPGLRGCFFSGTVNGERESLAAMSLCGGLSGSFLLAGEEFTIQPQGAGDSLDQPHRLQRWGPGQRREDPGLAAAEVFPLPQGLEWEVEMGDGQGQRRRDNEEDRERDKEGLRKETEDSREVTPPFGSKTRSKRFVSEARFVEILLVADASMAAFYGTDLQNHILTVMSMAARIYKHPSIRNSINLVVVKVLIVEEEGWGPEVSDNGGLTLRNFCSWQRRFNKPSDRHPEHYDTAILFTRQNFCRKGEQCDTLGMADVGTICDPNKSCSVIKDEGLQAAYTLAHELGHVLSMPHDDSKPCVRLFGPMGKYHMMAPFFIHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSVLPLPTGLPGHSTLYELDQQCKQIFGPDFRHCPNTSVEDICVQLWCRHRDSDEPICHTKNGSLLWADGTPCGPGHLCLDGSCVLREEVENPKAVVDGDWGPWGPWGQCSRTCGGGIQFSNRECDNPAPQNGGRFCLGERVKYQSCKTEECPPNGKSFREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFETKVIDGTLCGPDTLAICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTACRKVSGSFTPFSYGYNDIVTIPAGATNIDVKQRSHPGVQNDGSYLALKTANGQYLLNGNLAISAIEQDILMKGTILKYSGSMATLERLQSFQALPEPLTVQLLTVSGEVFPPKVKYTFFVPNDTDFNVQSSKERASTNIIQSLPYAEWVLGDWSECPSTCGGGWQRRTVECRDPSGQASDTCDEALKPEDAKPCGSQPCLL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias185-218Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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