D4AAT1 · D4AAT1_RAT
- ProteinADAM metallopeptidase with thrombospondin type 1 motif, 8
- GeneAdamts8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids905 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 237 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 237 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 320 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 320 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 327 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 378 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 379 | ||||
Binding site | 382 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 388 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 439 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 442 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 442 | Ca2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | extracellular matrix organization | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionD4AAT1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-28 | ||||
Chain | PRO_5035179060 | 29-905 | |||
Disulfide bond | 309↔362 | ||||
Disulfide bond | 338↔344 | ||||
Disulfide bond | 356↔439 | ||||
Disulfide bond | 394↔423 | ||||
Disulfide bond | 467↔492 | ||||
Disulfide bond | 478↔502 | ||||
Disulfide bond | 487↔523 | ||||
Disulfide bond | 517↔528 | ||||
Disulfide bond | 554↔591 | ||||
Disulfide bond | 558↔596 | ||||
Disulfide bond | 569↔581 | ||||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 139-163 | Disordered | |||
Region | 183-223 | Disordered | |||
Compositional bias | 185-218 | Basic and acidic residues | |||
Domain | 234-444 | Peptidase M12B | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length905
- Mass (Da)99,271
- Last updated2022-05-25 v4
- ChecksumC7B5F91D63288C2D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 185-218 | Basic and acidic residues | |||
Keywords
- Technical term