D3ZUC4 · AUNIP_RAT
- ProteinAurora kinase A- and ninein-interacting protein
- GeneAunip
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids347 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | site of DNA damage | |
Cellular Component | spindle pole | |
Molecular Function | damaged DNA binding | |
Biological Process | double-strand break repair via homologous recombination | |
Biological Process | negative regulation of double-strand break repair via nonhomologous end joining | |
Biological Process | spindle organization |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAurora kinase A- and ninein-interacting protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionD3ZUC4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000419631 | 1-347 | Aurora kinase A- and ninein-interacting protein | |||
Sequence: MSRRGPEEEACGVWLDAAALKRQKMQTHLLKLGTKMLTLLPGERKPSIPFTQRRATRQTSITSFVTSQPGMANGGNQKNASSLKENQINRECKSRSQLDCLDQGLEDDCLVSPLATSTPADIREAGHSPQSSQISGCQSLETTSLTMMSFPQPVVLMGTGESKAPLASSFTQFLERSCLLDQREAKRKREGLCGSKTDCPGMGSHIRPPGGKCHQPLDKAKVEKRATAKENRQAPVHLQTYRFGSHSGKKTLLVTKSPCPLSVFSWDIDRKDRDSWSQLFTEDSQGHQVIAHSTKMPFQDVTNARNQGSGQFPDSPQAQGQDGPTLLHLQPHLLFTQDSEGNRVIRH | ||||||
Modified residue | 284 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts (via C-terminus) with AURKA (via C-terminus). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B. Identified in a complex with NIN and AURKA. Interacts with RBBP8/CtIP.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 182-347 | Interaction with AURKA | ||||
Sequence: QREAKRKREGLCGSKTDCPGMGSHIRPPGGKCHQPLDKAKVEKRATAKENRQAPVHLQTYRFGSHSGKKTLLVTKSPCPLSVFSWDIDRKDRDSWSQLFTEDSQGHQVIAHSTKMPFQDVTNARNQGSGQFPDSPQAQGQDGPTLLHLQPHLLFTQDSEGNRVIRH | ||||||
Region | 273-347 | Interaction with RBBP8/CtIP | ||||
Sequence: RDSWSQLFTEDSQGHQVIAHSTKMPFQDVTNARNQGSGQFPDSPQAQGQDGPTLLHLQPHLLFTQDSEGNRVIRH | ||||||
Compositional bias | 301-324 | Polar residues | ||||
Sequence: VTNARNQGSGQFPDSPQAQGQDGP | ||||||
Region | 301-325 | Disordered | ||||
Sequence: VTNARNQGSGQFPDSPQAQGQDGPT |
Sequence similarities
Belongs to the AUNIP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)38,244
- Last updated2010-04-20 v1
- ChecksumB3858257513440F1
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I5ZKX2 | A0A8I5ZKX2_RAT | Aunip | 351 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 301-324 | Polar residues | ||||
Sequence: VTNARNQGSGQFPDSPQAQGQDGP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR06040351 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |