D3ZQT7 · D3ZQT7_RAT

  • Protein
    Methylcytosine dioxygenase TET
  • Gene
    Tet3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: The zinc ions have a structural role.

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular Componentfemale pronucleus
Cellular Componentmale pronucleus
Cellular Componentnucleus
Molecular Function5-methylcytosine dioxygenase activity
Molecular Functionmethyl-CpG binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Process5-methylcytosine catabolic process
Biological Processchromosomal 5-methylcytosine DNA demethylation pathway
Biological Processepigenetic programing of male pronucleus
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein O-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylcytosine dioxygenase TET
  • EC number

Gene names

    • Name
      Tet3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D3ZQT7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain50-90CXXC-type
Region137-174Disordered
Region229-249Disordered
Region294-316Disordered
Compositional bias368-383Polar residues
Region368-617Disordered
Compositional bias406-424Pro residues
Compositional bias490-506Pro residues
Compositional bias507-525Polar residues
Region631-710Disordered
Compositional bias680-700Polar residues
Region1351-1439Disordered
Compositional bias1388-1402Polar residues

Sequence similarities

Belongs to the TET family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,802
  • Mass (Da)
    194,534
  • Last updated
    2015-07-22 v3
  • Checksum
    CD64F5AA1D6B8D9F
MSQFQVPLAVQPDLSGLYDFPQGQVMVGGFQGPGLPMAGSETQLRGGGDGRKKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKAGLLKEVEINAREGTGPWAQGATVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAREPAGPSLLGAAGPWRVDQKPDWDAASGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNGRAPRPESCSEGGEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSAAMEGGQGRPRLPGTLPPSEAGLPAPSTRPLLSSEVPQVPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTSQASCPLPEALSPSAPFRSPQSYLRAPSWPVVPPEEHPSFAPDSPAFPPATPRTEFSEAWSTDTPPATPRNSWPVPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPPSSPAPAPSPISQREAPLPSSEPDTHQKAQTALQQHLHHKRNLFLEQAHDASFPTSTEPQAPGWWAPPGSPAPRPPDKPPKEKKKKPPTPAGGPVGAEKTTPGIKASVRKPIQIKKSRSRDMQPLFLPVRQIILEGLKPQASEGQAPTPAQLPVPPPASQGAASQSCATPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMVALQSGSTGGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQSTCLPTPESPFATRSPKKIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKKAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMATTDEFGSEENQNAKVSSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEKLSTPEKIKQEALELAGVTTDPGLSLQGGLPQQTLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGSCRPSDPYSMSSVYSYHSRYAQPGLASVNGFHSKYTLPSFGYYGFPSSNPVFPSQFLGPSAWGHGGGGGSFEKKPDLHALHNSLNPAYGGAEFAELPGQAVSTDNHHPAPHHQQPAYPGPKEYLLPKVPQLHPASRDPSPFAQSSGCYNRSIKQEPVDPLTQAEAVPRDSGKMSRTPLPEASQNGGPGHLWGQYSGGPSMSPKRTNSVGGNWGVFPSGESPTIVPDKLNSFGASCLTPSHFPDSQWGLFTGEGQQSAPHPGGRLRGKPWSPCKFGNGTSALSGPSLPEKPWGMGAGDFNSSLKGGPGFQDKLWNPVKVEEGRIPTPGANQLEKAWQAFGMPLSSNEKLFGALKSEEKLWDPFSLEEGTAEEPLSKGVVKEEKTGPGVEEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARQRQEEAARLGLGQQEAKLYGKKRKWGGAMVAEPQHKEKKGAVPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6A3Q7A0A8I6A3Q7_RATTet31783

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias368-383Polar residues
Compositional bias406-424Pro residues
Compositional bias490-506Pro residues
Compositional bias507-525Polar residues
Compositional bias680-700Polar residues
Compositional bias1388-1402Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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