D3ZQT7 · D3ZQT7_RAT
- ProteinMethylcytosine dioxygenase TET
- GeneTet3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1802 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H+ + succinate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | female pronucleus | |
Cellular Component | male pronucleus | |
Cellular Component | nucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | methyl-CpG binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | epigenetic programing of male pronucleus | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | protein O-linked glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionD3ZQT7
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-90 | CXXC-type | ||||
Sequence: GRKKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCE | ||||||
Region | 137-174 | Disordered | ||||
Sequence: DSGPVYHGDSRQLSTSGAPVNGAREPAGPSLLGAAGPW | ||||||
Region | 229-249 | Disordered | ||||
Sequence: SREAGNNGRAPRPESCSEGGE | ||||||
Region | 294-316 | Disordered | ||||
Sequence: EGGQGRPRLPGTLPPSEAGLPAP | ||||||
Compositional bias | 368-383 | Polar residues | ||||
Sequence: LPQPSHSTSQASCPLP | ||||||
Region | 368-617 | Disordered | ||||
Sequence: LPQPSHSTSQASCPLPEALSPSAPFRSPQSYLRAPSWPVVPPEEHPSFAPDSPAFPPATPRTEFSEAWSTDTPPATPRNSWPVPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPPSSPAPAPSPISQREAPLPSSEPDTHQKAQTALQQHLHHKRNLFLEQAHDASFPTSTEPQAPGWWAPPGSPAPRPPDKPPKEKKKKPPTPAGGPVGAEKTTPGIKASVRKPIQIKKSRSRDMQP | ||||||
Compositional bias | 406-424 | Pro residues | ||||
Sequence: VVPPEEHPSFAPDSPAFPP | ||||||
Compositional bias | 490-506 | Pro residues | ||||
Sequence: VEAPPSSPAPAPSPISQ | ||||||
Compositional bias | 507-525 | Polar residues | ||||
Sequence: REAPLPSSEPDTHQKAQTA | ||||||
Region | 631-710 | Disordered | ||||
Sequence: KPQASEGQAPTPAQLPVPPPASQGAASQSCATPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMVALQSGSTGGPLPPA | ||||||
Compositional bias | 680-700 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMVALQS | ||||||
Region | 1351-1439 | Disordered | ||||
Sequence: AVSTDNHHPAPHHQQPAYPGPKEYLLPKVPQLHPASRDPSPFAQSSGCYNRSIKQEPVDPLTQAEAVPRDSGKMSRTPLPEASQNGGPG | ||||||
Compositional bias | 1388-1402 | Polar residues | ||||
Sequence: DPSPFAQSSGCYNRS |
Sequence similarities
Belongs to the TET family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,802
- Mass (Da)194,534
- Last updated2015-07-22 v3
- ChecksumCD64F5AA1D6B8D9F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6A3Q7 | A0A8I6A3Q7_RAT | Tet3 | 1783 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 368-383 | Polar residues | ||||
Sequence: LPQPSHSTSQASCPLP | ||||||
Compositional bias | 406-424 | Pro residues | ||||
Sequence: VVPPEEHPSFAPDSPAFPP | ||||||
Compositional bias | 490-506 | Pro residues | ||||
Sequence: VEAPPSSPAPAPSPISQ | ||||||
Compositional bias | 507-525 | Polar residues | ||||
Sequence: REAPLPSSEPDTHQKAQTA | ||||||
Compositional bias | 680-700 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMVALQS | ||||||
Compositional bias | 1388-1402 | Polar residues | ||||
Sequence: DPSPFAQSSGCYNRS |
Keywords
- Technical term