D3ZG83 · M3K10_RAT

  • Protein
    Mitogen-activated protein kinase kinase kinase 10
  • Gene
    Map3k10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Activates the JUN N-terminal pathway.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site104-112ATP (UniProtKB | ChEBI)
Binding site125ATP (UniProtKB | ChEBI)
Active site222Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionbHLH transcription factor binding
Molecular FunctionJUN kinase kinase kinase activity
Molecular Functionprotein kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Molecular Functiontranscription corepressor activity
Biological Processnegative regulation of DNA-binding transcription factor activity
Biological Processnegative regulation of DNA-templated transcription
Biological Processpeptidyl-serine phosphorylation
Biological Processpeptidyl-threonine phosphorylation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of JUN kinase activity
Biological Processsmoothened signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase kinase kinase 10
  • EC number

Gene names

    • Name
      Map3k10

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D3ZG83

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00004448921-940Mitogen-activated protein kinase kinase kinase 10
Modified residue258Phosphothreonine; by autocatalysis
Modified residue262Phosphoserine; by autocatalysis and MAP4K1
Modified residue498Phosphoserine
Modified residue502Phosphoserine
Modified residue506Phosphoserine
Modified residue552Phosphothreonine
Modified residue843Omega-N-methylarginine

Post-translational modification

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer (By similarity).
Interacts with SH3RF2 (PubMed:22128169).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain16-81SH3
Domain98-360Protein kinase
Region384-405Leucine-zipper 1
Region419-440Leucine-zipper 2
Region490-599Disordered
Region639-658Disordered
Region687-733Disordered
Region748-916Disordered
Compositional bias763-777Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    940
  • Mass (Da)
    103,060
  • Last updated
    2015-07-22 v3
  • Checksum
    B39EDB486730A42D
MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAAPAAPTDLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMSQLSQEKPRVRKRKGNFKRSRLLKLREGSSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGSSGGSGTWSRSGPPKKEELVGGKKKGRTWGPSSTLQKERAGGEERLKALGEGSKQWSSSAPNLGKSPKHTPMAPGFASLNEMEEFAEADEGNNVPPSPYSTPSYLKVPLPAEASPCAQPPWEPPAATPSRPGHGARRRCDLALLGCATLLSAVGLGADVAEARAGDGEEQRGWLDGLFFPRPGRFPRGLSPTGRPGGRREETAPGFGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPTAPSPPPSLLPPSPSTNPLVDVELESFKKDPRQSLTPTHVTAAHAVSRGHRRTPSDGALRQREPPELTNHGPRDPLDFPRLPDPQALFPTRRRPLEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLSISPPSRPDTPESPGPLSVQPTLLDMDMEGQSQDNTVPLCGAYGSH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias763-777Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC120811
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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