D3ZG83 · M3K10_RAT
- ProteinMitogen-activated protein kinase kinase kinase 10
- GeneMap3k10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids940 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Activates the JUN N-terminal pathway.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 104-112 | ATP (UniProtKB | ChEBI) | |||
Binding site | 125 | ATP (UniProtKB | ChEBI) | |||
Active site | 222 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | bHLH transcription factor binding | |
Molecular Function | JUN kinase kinase kinase activity | |
Molecular Function | protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | transcription corepressor activity | |
Biological Process | negative regulation of DNA-binding transcription factor activity | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | peptidyl-serine phosphorylation | |
Biological Process | peptidyl-threonine phosphorylation | |
Biological Process | positive regulation of apoptotic process | |
Biological Process | positive regulation of JNK cascade | |
Biological Process | positive regulation of JUN kinase activity | |
Biological Process | smoothened signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase 10
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionD3ZG83
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000444892 | 1-940 | Mitogen-activated protein kinase kinase kinase 10 | ||
Modified residue | 258 | Phosphothreonine; by autocatalysis | |||
Modified residue | 262 | Phosphoserine; by autocatalysis and MAP4K1 | |||
Modified residue | 498 | Phosphoserine | |||
Modified residue | 502 | Phosphoserine | |||
Modified residue | 506 | Phosphoserine | |||
Modified residue | 552 | Phosphothreonine | |||
Modified residue | 843 | Omega-N-methylarginine | |||
Post-translational modification
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 16-81 | SH3 | |||
Domain | 98-360 | Protein kinase | |||
Region | 384-405 | Leucine-zipper 1 | |||
Region | 419-440 | Leucine-zipper 2 | |||
Region | 490-599 | Disordered | |||
Region | 639-658 | Disordered | |||
Region | 687-733 | Disordered | |||
Region | 748-916 | Disordered | |||
Compositional bias | 763-777 | Pro residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length940
- Mass (Da)103,060
- Last updated2015-07-22 v3
- ChecksumB39EDB486730A42D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 763-777 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC120811 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |