D3ZDG4 · D3ZDG4_RAT
- ProteinDraxin
- GeneDraxin
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids342 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | molecular adaptor activity | |
Biological Process | anterior commissure morphogenesis | |
Biological Process | axon guidance | |
Biological Process | commissural neuron differentiation in spinal cord | |
Biological Process | dorsal spinal cord development | |
Biological Process | forebrain development | |
Biological Process | hippocampal neuron apoptotic process | |
Biological Process | negative regulation of axon extension | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | negative regulation of hippocampal neuron apoptotic process | |
Biological Process | negative regulation of neuron projection development | |
Biological Process | neuron apoptotic process | |
Biological Process | Wnt signaling pathway |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDraxin
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionD3ZDG4
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-28 | |||||
Sequence: MAGSVLRVPMLFLILLLFPELYMTGTLA | ||||||
Chain | PRO_5009009430 | 29-342 | Draxin | |||
Sequence: SGSSARNLPETHSHLPSSALWVPQTSHHGRRGLGKKDRGPGRPRRTQEGAVVTATRQASQMTPGQPPAGLLQNKELLLGLALPYPEKEARSPGWERVKKRGREHKRRRDRLRLHRGRPAIRGPSSLMKKVEPSEDRMLESTMEESSTSLAPTMFFLTTADGAMPTVEESRILPVTSLRPQTQPTSDGEVMPTLDMALFDWTDYEDLKPEVWPSAKKKEKHWSHFTSDGNETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGLNNKCFDDCMCTEGLRCYAKFHRNRRVTRRKGRCVEPETANGDEGSFINI | ||||||
Disulfide bond | 267↔279 | |||||
Sequence: CDHHQDCLPGTCC | ||||||
Disulfide bond | 273↔286 | |||||
Sequence: CLPGTCCDLREHLC | ||||||
Disulfide bond | 278↔301 | |||||
Sequence: CCDLREHLCTPHNRGLNNKCFDDC | ||||||
Disulfide bond | 297↔309 | |||||
Sequence: CFDDCMCTEGLRC | ||||||
Disulfide bond | 303↔326 | |||||
Sequence: CTEGLRCYAKFHRNRRVTRRKGRC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 32-52 | Polar residues | ||||
Sequence: SARNLPETHSHLPSSALWVPQ | ||||||
Region | 32-77 | Disordered | ||||
Sequence: SARNLPETHSHLPSSALWVPQTSHHGRRGLGKKDRGPGRPRRTQEG | ||||||
Region | 120-154 | Disordered | ||||
Sequence: PGWERVKKRGREHKRRRDRLRLHRGRPAIRGPSSL | ||||||
Compositional bias | 127-145 | Basic residues | ||||
Sequence: KRGREHKRRRDRLRLHRGR |
Sequence similarities
Belongs to the draxin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length342
- Mass (Da)38,427
- Last updated2010-04-20 v1
- Checksum2C02836A732B40B2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 32-52 | Polar residues | ||||
Sequence: SARNLPETHSHLPSSALWVPQ | ||||||
Compositional bias | 127-145 | Basic residues | ||||
Sequence: KRGREHKRRRDRLRLHRGR |
Keywords
- Technical term