D3ZDG4 · D3ZDG4_RAT

Function

function

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionmolecular adaptor activity
Biological Processanterior commissure morphogenesis
Biological Processaxon guidance
Biological Processcommissural neuron differentiation in spinal cord
Biological Processdorsal spinal cord development
Biological Processforebrain development
Biological Processhippocampal neuron apoptotic process
Biological Processnegative regulation of axon extension
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of hippocampal neuron apoptotic process
Biological Processnegative regulation of neuron projection development
Biological Processneuron apoptotic process
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Draxin
  • Alternative names
    • Dorsal inhibitory axon guidance protein
    • Dorsal repulsive axon guidance protein

Gene names

    • Name
      Draxin
    • Synonyms
      DRAXIN

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    D3ZDG4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_500900943029-342Draxin
Disulfide bond267↔279
Disulfide bond273↔286
Disulfide bond278↔301
Disulfide bond297↔309
Disulfide bond303↔326

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with LRP6.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias32-52Polar residues
Region32-77Disordered
Region120-154Disordered
Compositional bias127-145Basic residues

Sequence similarities

Belongs to the draxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    342
  • Mass (Da)
    38,427
  • Last updated
    2010-04-20 v1
  • Checksum
    2C02836A732B40B2
MAGSVLRVPMLFLILLLFPELYMTGTLASGSSARNLPETHSHLPSSALWVPQTSHHGRRGLGKKDRGPGRPRRTQEGAVVTATRQASQMTPGQPPAGLLQNKELLLGLALPYPEKEARSPGWERVKKRGREHKRRRDRLRLHRGRPAIRGPSSLMKKVEPSEDRMLESTMEESSTSLAPTMFFLTTADGAMPTVEESRILPVTSLRPQTQPTSDGEVMPTLDMALFDWTDYEDLKPEVWPSAKKKEKHWSHFTSDGNETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGLNNKCFDDCMCTEGLRCYAKFHRNRRVTRRKGRCVEPETANGDEGSFINI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias32-52Polar residues
Compositional bias127-145Basic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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