Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance.Ciciliot S., Albiero M., Campanaro S., Poncina N., Tedesco S., Scattolini V., Dalla Costa F., Cignarella A., Vettore M.[...], Fadini G.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCFASEB J 32:4004-4015 (2018)Mapped to5
Role of p66shc in skeletal muscle function.Granatiero V., Gherardi G., Vianello M., Salerno E., Zecchini E., Toniolo L., Pallafacchina G., Murgia M., Blaauw B.[...], Mammucari C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCSci Rep 7:6283-6283 (2017)Mapped to5
Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system.Wolter J., Schild L., Bock F., Hellwig A., Gadi I., Al-Dabet M.M., Ranjan S., Ronicke R., Nawroth P.P.[...], Isermann B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCJ Thromb Haemost 14:2212-2226 (2016)Mapped to8
P66SHC deletion improves fertility and progeric phenotype of late- generation TERC-deficient mice but not their short lifespan.Giorgio M., Stendardo M., Migliaccio E., Pelicci P.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCAging Cell 15:446-454 (2016)Mapped to5
p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans.Ciciliot S., Albiero M., Menegazzo L., Poncina N., Scattolini V., Danesi A., Pagnin E., Marabita M., Blaauw B.[...], Fadini G.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCDiabetologia 58:2352-2360 (2015)Mapped to10
Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.Shahzad K., Bock F., Dong W., Wang H., Kopf S., Kohli S., Al-Dabet M.M., Ranjan S., Wolter J.[...], Isermann B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCKidney Int 87:74-84 (2015)Mapped to16
The influence of Shc proteins on life span in mice.Ramsey J.J., Tran D., Giorgio M., Griffey S.M., Koehne A., Laing S.T., Taylor S.L., Kim K., Cortopassi G.A.[...], McDonald R.B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCJ Gerontol A Biol Sci Med Sci 69:1177-1185 (2014)Mapped to5
Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1.Albiero M., Poncina N., Tjwa M., Ciciliot S., Menegazzo L., Ceolotto G., Vigili de Kreutzenberg S., Moura R., Giorgio M.[...], Fadini G.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCDiabetes 63:1353-1365 (2014)Mapped to33
The influence of shc proteins and aging on whole body energy expenditure and substrate utilization in mice.Stern J.H., Kim K., Ramsey J.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCPLoS One 7:e48790-e48790 (2012)Mapped to5
S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis.Capitani N., Patrussi L., Trentin L., Lucherini O.M., Cannizzaro E., Migliaccio E., Frezzato F., Gattazzo C., Forconi F.[...], Baldari C.T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCBlood 120:4391-4399 (2012)Mapped to13
Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.Vashistha H., Singhal P.C., Malhotra A., Husain M., Mathieson P., Saleem M.A., Kuriakose C., Seshan S., Wilk A.[...], Meggs L.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCAm J Physiol Renal Physiol 303:F1629-40 (2012)Mapped to14
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.Koss M., Bolze A., Brendolan A., Saggese M., Capellini T.D., Bojilova E., Boisson B., Prall O.W., Elliott D.A.[...], Selleri L.View abstractCategoriesSequences, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCDev. Cell 22:913-926 (2012)Cited in3Mapped to99+
NLRP5 mediates mitochondrial function in mouse oocytes and embryos.Fernandes R., Tsuda C., Perumalsamy A.L., Naranian T., Chong J., Acton B.M., Tong Z.B., Nelson L.M., Jurisicova A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCBiol. Reprod. 86:1-10 (2012)Cited in1Mapped to31
The p66Shc knocked out mice are short lived under natural condition.Giorgio M., Berry A., Berniakovich I., Poletaeva I., Trinei M., Stendardo M., Hagopian K., Ramsey J.J., Cortopassi G.[...], Pelicci P.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCAging Cell 11:162-168 (2012)Mapped to32
HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo.Salhan D., Pathak S., Husain M., Tandon P., Kumar D., Malhotra A., Meggs L.G., Singhal P.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCAm J Physiol Renal Physiol 302:F129-40 (2012)Mapped to5
A conditional knockout resource for the genome-wide study of mouse gene function.Skarnes W.C., Rosen B., West A.P., Koutsourakis M., Bushell W., Iyer V., Mujica A.O., Thomas M., Harrow J.[...], Bradley A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCNature 474:337-342 (2011)Mapped to99+
Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice.Berry A., Carnevale D., Giorgio M., Pelicci P.G., de Kloet E.R., Alleva E., Minghetti L., Cirulli F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCExp Gerontol 45:343-350 (2010)Mapped to5
EUCOMM--the European conditional mouse mutagenesis program.Friedel R.H., Seisenberger C., Kaloff C., Wurst W.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCBrief Funct Genomic Proteomic 6:180-185 (2007)Mapped to99+
Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.Berry A., Capone F., Giorgio M., Pelicci P.G., de Kloet E.R., Alleva E., Minghetti L., Cirulli F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCExp Gerontol 42:37-45 (2007)Mapped to5
Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.Menini S., Amadio L., Oddi G., Ricci C., Pesce C., Pugliese F., Giorgio M., Migliaccio E., Pelicci P.[...], Pugliese G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCDiabetes 55:1642-1650 (2006)Mapped to5
Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.Jiang S.T., Chiou Y.Y., Wang E., Lin H.K., Lin Y.T., Chi Y.C., Wang C.K., Tang M.J., Li H.View abstractCategoriesPhenotypes & VariantsSourceMGI: 98296PubMedEurope PMCAm J Pathol 168:205-220 (2006)Mapped to71
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage.Graiani G., Lagrasta C., Migliaccio E., Spillmann F., Meloni M., Madeddu P., Quaini F., Padura I.M., Lanfrancone L.[...], Emanueli C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCHypertension 46:433-440 (2005)Mapped to5
Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.Tachibana K., Jones N., Dumont D.J., Puri M.C., Bernstein A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCMol Cell Biol 25:4693-4702 (2005)Mapped to15
Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning.Koponen E., Voikar V., Riekki R., Saarelainen T., Rauramaa T., Rauvala H., Taira T., Castren E.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCMol Cell Neurosci 26:166-181 (2004)Mapped to47
Genetic mouse models of extended lifespan.Liang H., Masoro E.J., Nelson J.F., Strong R., McMahan C.A., Richardson A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 98296PubMedEurope PMCExp Gerontol 38:1353-1364 (2003)Mapped to28