D3Z3Z3 · D3Z3Z3_MOUSE
- ProteinVoltage-dependent L-type calcium channel subunit beta-3
- GeneCacnb3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids483 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit beta-3
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionD3Z3Z3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio. Interacts with CACNA2D4. Interacts with FASLG. Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 16-51 | Disordered | |||
Compositional bias | 28-51 | Basic and acidic residues | |||
Domain | 58-127 | SH3 | |||
Region | 128-169 | Disordered | |||
Compositional bias | 135-158 | Polar residues | |||
Compositional bias | 389-403 | Basic and acidic residues | |||
Region | 389-483 | Disordered | |||
Compositional bias | 404-419 | Polar residues | |||
Compositional bias | 457-483 | Basic and acidic residues | |||
Sequence similarities
Belongs to the calcium channel beta subunit family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length483
- Mass (Da)54,396
- Last updated2010-04-20 v1
- MD5 ChecksumEA0612907F2795BC2948225E4C70CBEE
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P54285 | CACB3_MOUSE | Cacnb3 | 484 | ||
A0A2U3TZ49 | A0A2U3TZ49_MOUSE | Cacnb3 | 457 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 28-51 | Basic and acidic residues | |||
Compositional bias | 135-158 | Polar residues | |||
Compositional bias | 389-403 | Basic and acidic residues | |||
Compositional bias | 404-419 | Polar residues | |||
Compositional bias | 457-483 | Basic and acidic residues | |||
Keywords
- Technical term