D3Z191 · D3Z191_MOUSE
- ProteinTransmembrane protein 106B
- GeneTmem106b
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids185 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Publications for D3Z191
TMEM106B regulates microglial proliferation and survival in response to demyelination.
- CategoriesFunction
- SourceMGI: 1919150
Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.
- CategoriesFunction, Expression, Phenotypes & Variants
- SourceMGI: 1919150
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-beta.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
The FTLD risk factor TMEM106B regulates the transport of lysosomes at the axon initial segment of motoneurons.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown.
- CategoriesFunction, Subcellular Location
- SourceMGI: 1919150
Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
- CategoriesFunction, Interaction
- SourceMGI: 1919150
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
- CategoriesFunction, Interaction
- SourceMGI: 1919150
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
A conditional knockout resource for the genome-wide study of mouse gene function.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150
EUCOMM--the European conditional mouse mutagenesis program.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1919150