D3Z120 · FOXI3_MOUSE

  • Protein
    Forkhead box protein I3
  • Gene
    Foxi3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development (PubMed:24650709, PubMed:26550799, PubMed:26992132, PubMed:30467319).
May act as a pioneer transcription factor during pharyngeal arch development (PubMed:26550799, PubMed:26992132).
Required for epithelial cell differentiation within the epidermis (PubMed:26450968).
Acts at multiple stages of otic placode induction: necessary for preplacodal ectoderm to execute an inner ear program (PubMed:26550799).
Required for hair follicle stem cell specification (PubMed:26992132).
Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (PubMed:31412026).

Features

Showing features for dna binding.

139950100150200250300350
TypeIDPosition(s)Description
DNA binding129-223Fork-head

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanatomical structure morphogenesis
Biological Processcell differentiation
Biological Processepidermal cell fate specification
Biological Processhair follicle development
Biological Processodontogenesis of dentin-containing tooth
Biological Processotic placode development
Biological Processparathyroid gland development
Biological Processpharyngeal system development
Biological Processregulation of transcription by RNA polymerase II
Biological Processthymus development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Forkhead box protein I3

Gene names

    • Name
      Foxi3

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    D3Z120
  • Secondary accessions
    • E0CZH3

Proteomes

Organism-specific databases

Subcellular Location

Nucleus

Keywords

Phenotypes & Variants

Disruption phenotype

Embryonic lethality due to impaired pharyngeal arches segmentation (PubMed:24650709).
Embryos fail to form endodermal pouches and this results in failed pharyngeal arches segmentation leading to severe defects in the skull, jaw, and ears (PubMed:24650709, PubMed:26550799).
Craniofacial neural crest cells undergo apoptosis in the mutant embryos at 10.0 day post coitum (dpc) (PubMed:24650709).
Conditional deletion in epithelium leads to fusion of molars with abnormally patterned shallow cusps (PubMed:26450968).
Conditional deletion impairs postnatal hair growth and hair cycling, resulting in poor hair regeneration upon hair plucking; defects are caused by progressive depletion of hair follicle stem cells (PubMed:26992132).
Conditional deletion also results in defects in the distal pharyngeal apparatus (PubMed:31412026).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis99-103Reduced transcription factor activity.
Mutagenesis200-224Knockin mice are significantly smaller and die immediately after birth. They show a partially truncated mandible and fusion of the upper and lower jaws (syngnathia) and anomalies of various bones of the ear.
Mutagenesis218Knockin mice hemizygous for L-218 mutant and a deletion of the wild-type Foxi3 allele fail to thrive after birth, are underweight, display respiratory abnormalities and die between birth and day 5.
Mutagenesis219-225Abolished localization to the nucleus.
Mutagenesis224Does not affect nuclear localization.
Mutagenesis258Does not affect transcription factor activity.
Mutagenesis266-268Does not affect transcription factor activity.
Mutagenesis385-393In Mut2; strongly reduced transcription factor activity.
Mutagenesis386-391In Mut1; reduced transcription factor activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004587541-399Forkhead box protein I3
Modified residue99Phosphoserine
Modified residue103Phosphoserine
Modified residue258Phosphoserine
Modified residue266Phosphoserine
Modified residue268Phosphoserine

Post-translational modification

Phosphorylation promotes the transcription factor activity (PubMed:30467319).
Dephosphorylation by protein phosphatase 2A (PP2A) reduces its activity (PubMed:30467319).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Specifically expressed in the epithelium in developing ectodermal appendages (PubMed:23441037).
Expressed in pharyngeal endoderm and ectoderm (PubMed:24650709).
Expressed in pre-placodal ectoderm (PubMed:26550799).
Down-regulated as the otic placode is induced (PubMed:26550799).
Expressed in teeth and hair follicles throughout embryogenesis (PubMed:23441037).
Expressed in mammary glands only during the earliest stages of development (PubMed:23441037).

Induction

Regulated by ectodysplasin (EDA) in skin appendage placodes.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif, compositional bias.

TypeIDPosition(s)Description
Region87-109Disordered
Motif219-225Nuclear localization signal
Region221-287Disordered
Compositional bias229-248Polar residues
Compositional bias260-287Polar residues
Region307-353Disordered
Motif385-3939aaTAD

Domain

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    399
  • Mass (Da)
    42,015
  • Last updated
    2011-04-05 v2
  • Checksum
    B6AF74DCAD855C58
MALYCGDNFVYSQPAAAPGAPPTSRAPYGLSDYAAPPAAAANPYLWLNGPGVGGPASAASYLGAPPPPPGAAPGPFLQPPAAPGTFAGAQRGFAQPSASAPASPAGSAAPGELGWLSMASREDLMKMVRPPYSYSALIAMAIQSAPERKLTLSHIYQFVADNFPFYQRSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRRRRAEASSNLTVPSGTSKSEGQSSRLRVSGKLEGDSPSSILRPSQSPEPPEGTKSTASSPGASTLTSTPCLNTFLSTFNTLNVNSSSSMGNQRTLPGSRRHLGGTQLPSSTFPNTSVPDSSPDSMQLSTVGGSNQLSSYYNPFSGGSSGDQSSPFSSPFYNFSMVNSLIYPRDGSDI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A9S4I865A0A9S4I865_MOUSEFoxi3425

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias229-248Polar residues
Compositional bias260-287Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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