Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
Modernizing reference genome assemblies.Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., Chen H.C., Agarwala R., McLaren W.M.[...], Hubbard T.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol 9:e1001091-e1001091 (2011)Cited in99+
No title available.EnsemblCited forIDENTIFICATIONStrainC57BL/6JSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to UniProtKB (JUN-2024)Cited in99+
Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.Liu S.K., McGlade C.J.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCOncogene 17:3073-3082 (1998)Cited in1Mapped to20
The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway.Okada S., Kao A.W., Ceresa B.P., Blaikie P., Margolis B., Pessin J.E.View abstractCategoriesSequencesSourceMGI: 98296PubMedEurope PMCJ Biol Chem 272:28042-28049 (1997)Mapped to5
Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.Harmer S.L., DeFranco A.L.View abstractCategoriesPTM / Processing, InteractionSourceMGI: 98296PubMedEurope PMCMol Cell Biol 17:4087-4095 (1997)Mapped to99+
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.Migliaccio E., Mele S., Salcini A.E., Pelicci G., Lai K.M., Superti-Furga G., Pawson T., Di Fiore P.P., Lanfrancone L., Pelicci P.-G.View abstractCategoriesSequencesSourceMGI: 98296PubMedEurope PMCEMBO J. 16:706-716 (1997)Cited in1Mapped to5
Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen- activated protein kinase (MAPK) in mammary epithelial cells.Kannan S., De Santis M., Lohmeyer M., Riese D.J., Smith G.H., Hynes N., Seno M., Brandt R., Bianco C.[...], Salomon D.S.View abstractCategoriesFunctionSourceMGI: 98296PubMedEurope PMCJ Biol Chem 272:3330-3335 (1997)Mapped to17
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.Chook Y.M., Gish G.D., Kay C.M., Pai E.F., Pawson T.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCJ Biol Chem 271:30472-30478 (1996)Mapped to21
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.Borg J.-P., Ooi J., Levy E., Margolis B.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCMol. Cell. Biol. 16:6229-6241 (1996)Cited in2Mapped to9
Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.Dey B.R., Frick K., Lopaczynski W., Nissley S.P., Furlanetto R.W.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCMol Endocrinol 10:631-641 (1996)Mapped to11
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.O'Bryan J.P., Songyang Z., Cantley L., Der C.J., Pawson T.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 93:2729-2734 (1996)Cited in1Mapped to22
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.Rozakis-Adcock M., Fernley R., Wade J., Pawson T., Bowtell D.View abstractCategoriesFunctionSourceMGI: 98296PubMedEurope PMCNature 363:83-85 (1993)Mapped to19
Shc products are substrates of erbB-2 kinase.Segatto O., Pelicci G., Giuli S., Digiesi G., Di Fiore P.P., McGlade J., Pawson T., Pelicci P.G.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCOncogene 8:2105-2112 (1993)Mapped to22
A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways.Sakaue M., Bowtell D., Kasuga M.View abstractCategoriesFunctionSourceMGI: 98296PubMedEurope PMCMol Cell Biol 15:379-388 (1995)Mapped to11
A region in Shc distinct from the SH2 domain can bind tyrosine- phosphorylated growth factor receptors.Blaikie P.A., Immanuel D., Wu J., Li N., Yajnik V., Margolis B.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCJ. Biol. Chem. 269:32031-32034 (1994)Cited in1Mapped to10
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.Suen K., Bustelo X.R., Pawson T., Barbacid M.View abstractCategoriesSequences, InteractionSourceMGI: 98296PubMedEurope PMCMol. Cell. Biol. 13:5500-5512 (1993)Cited in1Mapped to29
Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.Galisteo M.L., Dikic I., Batzer A.G., Langdon W.Y., Schlessinger J.View abstractCategoriesFunction, InteractionSourceMGI: 98296PubMedEurope PMCJ. Biol. Chem. 270:20242-20245 (1995)Cited in2Mapped to32
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.VanderKuur J., Allevato G., Billestrup N., Norstedt G., Carter-Su C.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCJ Biol Chem 270:7587-7593 (1995)Mapped to24
Interaction of Shc with Grb2 regulates association of Grb2 with mSOS.Ravichandran K.S., Lorenz U., Shoelson S.E., Burakoff S.J.View abstractCategoriesInteractionSourceMGI: 98296PubMedEurope PMCMol Cell Biol 15:593-600 (1995)Mapped to10
p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation.Lopresti L., Capitani N., Tatangelo V., Tangredi C., Boncompagni G., Frezzato F., Visentin A., Marotta G., Ciofini S.[...], Patrussi L.View abstractSourceMGI: 98296PubMedEurope PMCFront Cell Dev Biol 12:1297116-1297116 (2024)Mapped to5
The longevity protein p66<sup>Shc</sup> is required for neonatal heart regeneration.Huang C., Ding T., Zhang Y., Li X., Sun X., Lv S., Hao Y., Bai L., Liu N.[...], Nie Y.View abstractCategoriesFunctionSourceMGI: 98296PubMedEurope PMCJ Mol Cell Cardiol 177:21-27 (2023)Mapped to5
SIRT1 attenuates blood-spinal cord barrier disruption after spinal cord injury by deacetylating p66Shc.Jiang T., Qin T., Gao P., Tao Z., Wang X., Wu M., Gu J., Chu B., Zheng Z.[...], Yin G.View abstractCategoriesFunctionSourceMGI: 98296PubMedEurope PMCRedox Biol 60:102615-102615 (2023)Mapped to12
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.Bedogni F., Hevner R.F.View abstractCategoriesFunctionSourceMGI: 98296PubMedEurope PMCFront Mol Neurosci 14:686034-686034 (2021)Mapped to99+
Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy.Hirschhauser C., Sydykov A., Wolf A., Esfandiary A., Bornbaum J., Kutsche H.S., Boengler K., Sommer N., Schreckenberg R.[...], Schulz R.View abstractCategoriesFunctionSourceMGI: 98296PubMedEurope PMCInt J Mol Sci 21:E9339-E9339 (2020)Mapped to5