D3YZN5 · D3YZN5_MOUSE
- ProteinDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- GeneStt3a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N4-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H+
a di-trans,poly-cis-dolichyl diphosphooligosaccharide RHEA-COMP:19509 + RHEA-COMP:12804 = RHEA-COMP:12805 + a di-trans,poly-cis-dolichyl diphosphate RHEA-COMP:19506 + CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Protein modification; protein glycosylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | dolichyl-diphosphooligosaccharide-protein glycotransferase activity | |
Molecular Function | metal ion binding | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionD3YZN5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-90 | Oligosaccharyl transferase STT3 N-terminal | ||||
Sequence: LLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYP |
Sequence similarities
Belongs to the STT3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length90
- Mass (Da)10,755
- Last updated2010-04-20 v1
- ChecksumC72092731DA0ADDC
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P46978 | STT3A_MOUSE | Stt3a | 705 | ||
D6RDS9 | D6RDS9_MOUSE | Stt3a | 69 | ||
F6YHG5 | F6YHG5_MOUSE | Stt3a | 112 | ||
A0A1L1SSD1 | A0A1L1SSD1_MOUSE | Stt3a | 60 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 90 | |||||
Sequence: P |
Keywords
- Technical term