D3YZG8 · MTD2L_MOUSE
- ProteinBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- GeneMthfd2l
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids338 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD+ = (6R)-5,10-methenyltetrahydrofolate + NADH
Cofactor
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial matrix | |
Cellular Component | mitochondrion | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NAD+) activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | 10-formyltetrahydrofolate metabolic process | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
- Alternative names
Including 2 domains:
- Recommended nameNAD-dependent methylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionD3YZG8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000413328 | 1-338 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial | |||
Sequence: MATRARGFSLLRGRLGRGPVRAPGVAERAWRGFGSSGRRHEAVIISGTNMAKQIQKEIQQGVESWIALGNRRPHLSIILVGDNPASHTYVRNKIKAASAVGICSELIIKPKNVSQEELLDITDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPREQLKAHTQLADIIIVAAGIPRLITADMVREGAAVIDVGINYIQDPVTGKTKLVGDVDFEAVKKKASFITPVPGGVGPMTVAMLLKNTLLAAKNIAY |
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed.
Developmental stage
Expressed at all embryonic days examined in the neural tube and the forebrain, midbrain, and hindbrain. Also detected in the branchial arches and limb buds, particularly along the progress zone. Expression is low at 8.5 dpc but increases at 10.5 dpc.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length338
- Mass (Da)36,438
- Last updated2010-04-20 v1
- Checksum71A447A15C918D8E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0J9YUR4 | A0A0J9YUR4_MOUSE | Mthfd2l | 62 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC109311 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC157938 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466617 EMBL· GenBank· DDBJ | EDL05299.1 EMBL· GenBank· DDBJ | Genomic DNA |