D3YZG8 · MTD2L_MOUSE

  • Protein
    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
  • Gene
    Mthfd2l
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site89-93substrate
Binding site136-138substrate
Binding site205-207NAD+ (UniProtKB | ChEBI)
Binding site238NAD+ (UniProtKB | ChEBI)
Binding site314-318substrate

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NAD+) activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological Process10-formyltetrahydrofolate metabolic process
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial
  • Alternative names
    • NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein
      (MTHFD2-like
      )

Including 2 domains:

  • Recommended name
    NAD-dependent methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      Mthfd2l

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    D3YZG8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004133281-338Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed.

Developmental stage

Expressed at all embryonic days examined in the neural tube and the forebrain, midbrain, and hindbrain. Also detected in the branchial arches and limb buds, particularly along the progress zone. Expression is low at 8.5 dpc but increases at 10.5 dpc.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    338
  • Mass (Da)
    36,438
  • Last updated
    2010-04-20 v1
  • Checksum
    71A447A15C918D8E
MATRARGFSLLRGRLGRGPVRAPGVAERAWRGFGSSGRRHEAVIISGTNMAKQIQKEIQQGVESWIALGNRRPHLSIILVGDNPASHTYVRNKIKAASAVGICSELIIKPKNVSQEELLDITDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPREQLKAHTQLADIIIVAAGIPRLITADMVREGAAVIDVGINYIQDPVTGKTKLVGDVDFEAVKKKASFITPVPGGVGPMTVAMLLKNTLLAAKNIAY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0J9YUR4A0A0J9YUR4_MOUSEMthfd2l62

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC109311
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC157938
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466617
EMBL· GenBank· DDBJ
EDL05299.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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