D3YYM4 · WDR72_MOUSE

  • Protein
    WD repeat-containing protein 72
  • Gene
    Wdr72
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Plays a major role in formation of tooth enamel (PubMed:25008349, PubMed:26247047).
Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins (PubMed:25008349, PubMed:26247047).
May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane (PubMed:26247047).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentendosome
Cellular Componentnucleus
Biological Processenamel mineralization
Biological Processextracellular matrix disassembly
Biological Processprotein localization to plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    WD repeat-containing protein 72

Gene names

    • Name
      Wdr72

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    D3YYM4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Viable with no gross morpholgical defects (PubMed:25008349, PubMed:26247047).
At 6-7 weeks of age teeth have an opaque, chalky appearance, with reduced enamel thickness at occlusal surfaces (PubMed:25008349, PubMed:26247047).
Body weight is reduced, probably due to problems with chewing hard foods (PubMed:25008349).
Enamel formation is abnormal from the maturation stage onwards with significantly reduced mineral density and retention of proteinaceous material in the enamel matrix (PubMed:25008349, PubMed:26247047).
Tooth enamel hardness is ten times lower than wild type (PubMed:26247047).
Attachment of ameloblasts to the enamel layer may be weakened (PubMed:26247047).
The calcium transporter SLC24A4 fails to localize to the distal ameloblast membrane (PubMed:26247047).
In maturation stage ameloblasts expression levels of amelogenin appear to be reduced, although abnormally high amelogenin levels are found in the extracellular enamel matrix (PubMed:25008349, PubMed:26247047).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 63 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004381881-1114WD repeat-containing protein 72
Modified residue1093Phosphoserine
Modified residue1095Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in maturation stage ameloblasts (at protein level) (PubMed:19853237, PubMed:25008349).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for repeat, region, compositional bias.

TypeIDPosition(s)Description
Repeat15-54WD 1
Repeat60-102WD 2
Repeat160-197WD 3
Repeat327-373WD 4
Repeat413-452WD 5
Repeat470-515WD 6
Repeat566-605WD 7
Region634-658Disordered
Compositional bias749-773Polar residues
Region749-798Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,114
  • Mass (Da)
    124,410
  • Last updated
    2010-04-20 v1
  • Checksum
    209D3BF22B75E72C
MRGALQAVALWGRKAPPHSITAIMITDDQQTIVTGSQEGQLCLWSLSPELKISAKELLFGHSASVTCLARARDFSKQPYVVSAAENGEMCMWNVSSGQCVEKTSLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLVLDAGTLAVLHTFTSLQSPDWMKCMCIVHSVRIQEDSLLVVSITGELKVWDLSSSINSIQEKQDVHEKESKFLDSFNCQTIRFCPYTERLLLVVFSKCWKIYDYCDFSLLWTEVSRDGQFFAGGEVLAAHRILVWTEDGHSYIYQLLNRWAQMGATLRTFSGLSKCVCPADGGVLKGTVYPHLLCSTSVEENKSLHFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPISKFDGSPREIPITTTWTLQDNFDKHQMVSQSITDHFSGSRDEVGMTATITSSEYIPNLDKLICGCEDGTIFITKALNAAKAGLLEGDSLLKDSPCHTLLRGHHQSVTSLLYPHNLASKLDQSWMVSGDRGSYVILWDIFTEEILHTFFLEAGPVTRLLMSPENLKRSDGQILCCVCGDHSVALLHLEGRRCLLRARKHLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARIILNCGDDAQLIRSEPTLSVASETHKHKSIEQKSSNSHQPGPVPCPSVQLESSCKVADASSVPRPFNVLPVKTKWSHIGFHVLLFDLENLVELLLPTPLSDVDPSGSFYGGDILRRAKSTVEKKTLTIRRNKASCSSLQTEAQAKPSGDSLVLGDSTSKFSEENNGIKRQKKMKSSKKAHPKPPRKVDASLTIDMAKLFLSCILPWGVDKDLDSLCTRHLSILKLQGPVSLGLASNEDLFSLMLPGWDACSTEMKEYSGVNLCSRKVLDLSSKYTATLLHQTGIPRGLESHCDSVQQSDAIVYLLSRLFLVNKLVNMPLDLACEIDRPFKMETVHSKARFPGSDILNISSFYGHPKNGGNECRAPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLRNTPVSSQPDPVAEHSICERMQISAKMEWTEELELQYVGKSSPLKTSVSPVKHGNDLNSANFQDTEDILDRCVLEESESAGQPRHRPWIAKVCSCRMC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1L1SR77A0A1L1SR77_MOUSEWdr721102

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias749-773Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC108944
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC111087
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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